Succinate-semialdehyde dehydrogenase

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In enzymology, a succinate-semialdehyde dehydrogenase (EC 1.2.1.24) is an enzyme that catalyzes the chemical reaction

succinate semialdehyde + NAD⁺ + H₂O succinate + NADH + 2 H⁺

The 3 substrates of this enzyme are succinate semialdehyde, NAD⁺, and H₂O, whereas its 3 products are succinate, NADH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is succinate-semialdehyde:NAD+ oxidoreductase. Other names in common use include succinate semialdehyde dehydrogenase, succinic semialdehyde dehydrogenase, succinyl semialdehyde dehydrogenase, and succinate semialdehyde:NAD+ oxidoreductase. This enzyme participates in glutamate and butanoate metabolism.

[edit] References

• IUBMB entry for 1.2.1.24
• BRENDA references for 1.2.1.24 (Recommended.)
• PubMed references for 1.2.1.24
• PubMed Central references for 1.2.1.24
• Google Scholar references for 1.2.1.24
• ALBERS RW, KOVAL GJ (1961). "Succinic semialdehyde dehydrogenase: purification and properties of the enzyme from monkey brain". Biochim. Biophys. Acta. 52: 29–35. PMID 13860092. 

[edit] External links

The CAS registry number for this enzyme class is 9028-95-9.

• IUBMB entry for 1.2.1.24

• KEGG entry for 1.2.1.24

• BRENDA entry for 1.2.1.24

• NiceZyme view of 1.2.1.24

• EC2PDB: PDB structures for 1.2.1.24

• PRIAM entry for 1.2.1.24

• PUMA2 entry for 1.2.1.24

• IntEnz: Integrated Enzyme entry for 1.2.1.24

• MetaCyc entry for 1.2.1.24

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004777: succinate-semialdehyde dehydrogenase

• AMIGO entry for GO code 0004777: succinate-semialdehyde dehydrogenase