Subiculum

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Brain: Subiculum
Subiculum labeled at center left.
Subiculum to CA1 transition Artist Don Cooper and Leah Leverich
Part of	Temporal lobe
Artery	Posterior cerebral Anterior choroidal
Acronym(s)	S
NeuroNames	hier-170
MeSH	Subiculum

The subiculum (Latin for "support") is the most inferior component of the hippocampal formation. It lies between the entorhinal cortex and the CA1 subfield of the hippocampus proper.

It receives input from CA1 and entorhinal cortical layer III pyramidal neurons and is the main output of the hippocampus. The pyramidal neurons send projections to the nucleus accumbens, septal nuclei, prefrontal cortex, hypothalamus, entorhinal cortex and amygdala.

The pyramidal neurons in the subiculum exhibit transitions between two modes of action potential output: bursting and single spiking. The transitions between these two modes is thought to be important for routing information out of the hippocampus.

It is the site responsible for ictal activity in some cases of human epilepsy. It has also been implicated in working memory and drug addiction.

[edit] References

• "Switching Signals in the Brain," PLoS Biology, 3(6):e210, 2005 June.
• Donald C. Cooper, Sungkwon Chung, Nelson Spruston, "Output-Mode Transitions Are Controlled by Prolonged Inactivation of Sodium Channels in Pyramidal Neurons of Subiculum," PLoS Biology, 3(6):e175, 2005 June.
• Donald C. Cooper, Shannon J. Moore, Nathan P. Staff, and Nelson Spruston, "Psychostimulant-induced plasticity of intrinsic excitability in the ventral subiculum," Journal of Neuroscience, October 29, 2003, 23(30):9937-9946

[edit] External links

• NeuroNames hier-170
• MeSH Hippocampus
• Photo
• Photo
• BrainMaps at UCDavis Subiculum

v • d • e Human brain: Limbic system Diencephalon Hypothalamus · Mammillary body Telencephalon: limbic lobe Archicortex: Hippocampal formation (Hippocampus, Alveus of the hippocampus, Subiculum, Perforant path, Fimbria, Dentate gyrus) · Paraterminal gyrus · Supracallosal gyrus Cingulate gyrus · Parahippocampal gyrus · Uncus Telencephalon: other Amygdala · Nucleus accumbens · Orbitofrontal cortex septum: Septum pellucidum, Septal nuclei

v • d • e Papez circuit Diencephalon Mammillary body → Mammillothalamic tract → Anterior thalamic nucleus → Telencephalon Anterior limb of internal capsule → Cingulate gyrus → Cingulum → Parahippocampal gyrus → Entorhinal cortex → Perforant path → Hippocampus/Hippocampal formation (Subiculum) → Fornix →