STX5

From Wikipedia, the free encyclopedia

Syntaxin 5

Identifiers

STX5; SED5; STX5A

External IDs

OMIM: 603189 MGI: 1928483 HomoloGene: 2381

Gene ontology
Molecular Function:	• protein transporter activity
Cellular Component:	• membrane • integral to membrane
Biological Process:	• transport • intracellular protein transport • vesicle targeting

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

XM_001128716 (mRNA)
XP_001128716 (protein)

NM_019829 (mRNA)
NP_062803 (protein)

Location

Chr 11: 62.33 - 62.36 Mb

Chr 19: 8.81 - 8.82 Mb

Pubmed search

[1]

[2]

Syntaxin 5, also known as STX5, is a human gene.^[1]

[edit] References

^ Entrez Gene: STX5 syntaxin 5.

[edit] Further reading

Nichols BJ, Pelham HR (1998). "SNAREs and membrane fusion in the Golgi apparatus.". Biochim. Biophys. Acta 1404 (1-2): 9–31. PMID 9714710.
Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells.". Cell 89 (1): 149–58. PMID 9094723.
Paek I, Orci L, Ravazzola M, et al. (1997). "ERS-24, a mammalian v-SNARE implicated in vesicle traffic between the ER and the Golgi.". J. Cell Biol. 137 (5): 1017–28. PMID 9166403.
Ravichandran V, Roche PA (1997). "Cloning and identification of human syntaxin 5 as a synaptobrevin/VAMP binding protein.". J. Mol. Neurosci. 8 (2): 159–61. PMID 9188044.
Rabouille C, Kondo H, Newman R, et al. (1998). "Syntaxin 5 is a common component of the NSF- and p97-mediated reassembly pathways of Golgi cisternae from mitotic Golgi fragments in vitro.". Cell 92 (5): 603–10. PMID 9506515.
Hay JC, Klumperman J, Oorschot V, et al. (1998). "Localization, dynamics, and protein interactions reveal distinct roles for ER and Golgi SNAREs.". J. Cell Biol. 141 (7): 1489–502. PMID 9647643.
Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1.". J. Leukoc. Biol. 65 (3): 397–406. PMID 10080545.
Xu D, Joglekar AP, Williams AL, Hay JC (2001). "Subunit structure of a mammalian ER/Golgi SNARE complex.". J. Biol. Chem. 275 (50): 39631–9. doi:10.1074/jbc.M007684200. PMID 11035026.
Shorter J, Beard MB, Seemann J, et al. (2002). "Sequential tethering of Golgins and catalysis of SNAREpin assembly by the vesicle-tethering protein p115.". J. Cell Biol. 157 (1): 45–62. doi:10.1083/jcb.200112127. PMID 11927603.
Parlati F, Varlamov O, Paz K, et al. (2002). "Distinct SNARE complexes mediating membrane fusion in Golgi transport based on combinatorial specificity.". Proc. Natl. Acad. Sci. U.S.A. 99 (8): 5424–9. doi:10.1073/pnas.082100899. PMID 11959998.
Xu Y, Martin S, James DE, Hong W (2003). "GS15 forms a SNARE complex with syntaxin 5, GS28, and Ykt6 and is implicated in traffic in the early cisternae of the Golgi apparatus.". Mol. Biol. Cell 13 (10): 3493–507. doi:10.1091/mbc.E02-01-0004. PMID 12388752.
Uchiyama K, Jokitalo E, Kano F, et al. (2003). "VCIP135, a novel essential factor for p97/p47-mediated membrane fusion, is required for Golgi and ER assembly in vivo.". J. Cell Biol. 159 (5): 855–66. doi:10.1083/jcb.200208112. PMID 12473691.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Dulubova I, Yamaguchi T, Arac D, et al. (2003). "Convergence and divergence in the mechanism of SNARE binding by Sec1/Munc18-like proteins.". Proc. Natl. Acad. Sci. U.S.A. 100 (1): 32–7. doi:10.1073/pnas.232701299. PMID 12506202.
Williams AL, Ehm S, Jacobson NC, et al. (2004). "rsly1 binding to syntaxin 5 is required for endoplasmic reticulum-to-Golgi transport but does not promote SNARE motif accessibility.". Mol. Biol. Cell 15 (1): 162–75. doi:10.1091/mbc.E03-07-0535. PMID 14565970.
Hirose H, Arasaki K, Dohmae N, et al. (2005). "Implication of ZW10 in membrane trafficking between the endoplasmic reticulum and Golgi.". EMBO J. 23 (6): 1267–78. doi:10.1038/sj.emboj.7600135. PMID 15029241.
Suga K, Tomiyama T, Mori H, Akagawa K (2004). "Syntaxin 5 interacts with presenilin holoproteins, but not with their N- or C-terminal fragments, and affects beta-amyloid peptide production.". Biochem. J. 381 (Pt 3): 619–28. doi:10.1042/BJ20040618. PMID 15109302.
Tai G, Lu L, Wang TL, et al. (2005). "Participation of the syntaxin 5/Ykt6/GS28/GS15 SNARE complex in transport from the early/recycling endosome to the trans-Golgi network.". Mol. Biol. Cell 15 (9): 4011–22. doi:10.1091/mbc.E03-12-0876. PMID 15215310.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.