STX11

From Wikipedia, the free encyclopedia

Syntaxin 11

Identifiers

STX11; FHL4; HLH4; HPLH4

External IDs

OMIM: 605014 MGI: 1921982 HomoloGene: 2792

Gene ontology
Molecular Function:	• SNAP receptor activity • protein binding • protein transporter activity
Cellular Component:	• membrane
Biological Process:	• intracellular protein transport • membrane fusion

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003764 (mRNA)
NP_003755 (protein)

XM_203312 (mRNA)
XP_203312 (protein)

Location

Chr 6: 144.51 - 144.55 Mb

Chr 10: 12.63 - 12.65 Mb

Pubmed search

[1]

[2]

Syntaxin 11, also known as STX11, is a human gene.^[1]

[edit] References

^ Entrez Gene: STX11 syntaxin 11.

[edit] Further reading

Advani RJ, Bae HR, Bock JB, et al. (1998). "Seven novel mammalian SNARE proteins localize to distinct membrane compartments.". J. Biol. Chem. 273 (17): 10317–24. PMID 9553086.
Tang BL, Low DY, Hong W (1998). "Syntaxin 11: a member of the syntaxin family without a carboxyl terminal transmembrane domain.". Biochem. Biophys. Res. Commun. 245 (2): 627–32. doi:10.1006/bbrc.1998.8490. PMID 9571206.
Valdez AC, Cabaniols JP, Brown MJ, Roche PA (1999). "Syntaxin 11 is associated with SNAP-23 on late endosomes and the trans-Golgi network.". J. Cell. Sci. 112 ( Pt 6): 845–54. PMID 10036234.
Martín-Martín B, Nabokina SM, Lazo PA, Mollinedo F (1999). "Co-expression of several human syntaxin genes in neutrophils and differentiating HL-60 cells: variant isoforms and detection of syntaxin 1.". J. Leukoc. Biol. 65 (3): 397–406. PMID 10080545.
Roperch JP, Lethrone F, Prieur S, et al. (1999). "SIAH-1 promotes apoptosis and tumor suppression through a network involving the regulation of protein folding, unfolding, and trafficking: identification of common effectors with p53 and p21(Waf1).". Proc. Natl. Acad. Sci. U.S.A. 96 (14): 8070–3. PMID 10393949.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
zur Stadt U, Schmidt S, Kasper B, et al. (2005). "Linkage of familial hemophagocytic lymphohistiocytosis (FHL) type-4 to chromosome 6q24 and identification of mutations in syntaxin 11.". Hum. Mol. Genet. 14 (6): 827–34. doi:10.1093/hmg/ddi076. PMID 15703195.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Yamamoto K, Ishii E, Horiuchi H, et al. (2006). "Mutations of syntaxin 11 and SNAP23 genes as causes of familial hemophagocytic lymphohistiocytosis were not found in Japanese people.". J. Hum. Genet. 50 (11): 600–3. doi:10.1007/s10038-005-0293-1. PMID 16180048.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Zur Stadt U, Beutel K, Kolberg S, et al. (2006). "Mutation spectrum in children with primary hemophagocytic lymphohistiocytosis: molecular and functional analyses of PRF1, UNC13D, STX11, and RAB27A.". Hum. Mutat. 27 (1): 62–8. doi:10.1002/humu.20274. PMID 16278825.
Bryceson YT, Rudd E, Zheng C, et al. (2007). "Defective cytotoxic lymphocyte degranulation in syntaxin-11 deficient familial hemophagocytic lymphohistiocytosis 4 (FHL4) patients.". Blood 110 (6): 1906–15. doi:10.1182/blood-2007-02-074468. PMID 17525286.
Arneson LN, Brickshawana A, Segovis CM, et al. (2007). "Cutting edge: syntaxin 11 regulates lymphocyte-mediated secretion and cytotoxicity.". J. Immunol. 179 (6): 3397–401. PMID 17785771.