Stratifin

From Wikipedia, the free encyclopedia

Stratifin

PDB rendering based on 1ywt.

Available structures: 1ywt, 1yz5

Identifiers

Symbol(s)

SFN; YWHAS

External IDs

OMIM: 601290 MGI: 1891831 HomoloGene: 4475

Gene ontology
Molecular Function:	• protein kinase C inhibitor activity • protein domain specific binding
Cellular Component:	• extracellular space • cytoplasm
Biological Process:	• regulation of cyclin-dependent protein kinase activity • negative regulation of protein kinase activity • signal transduction • cell proliferation • keratinocyte differentiation • skin development

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_006142 (mRNA)
NP_006133 (protein)

NM_018754 (mRNA)
NP_061224 (protein)

Location

Chr 1: 27.06 - 27.06 Mb

Chr 4: 132.87 - 132.87 Mb

Pubmed search

[1]

[2]

Stratifin, also known as SFN, is a human gene.^[1]

[edit] References

^ Entrez Gene: SFN stratifin.

[edit] Further reading

Hermeking H (2005). "Extracellular 14-3-3sigma protein: a potential mediator of epithelial-mesenchymal interactions.". J. Invest. Dermatol. 124 (1): ix-x. doi:10.1111/j.0022-202X.2004.23534.x. PMID 15654940.
Mhawech P (2005). "14-3-3 proteins--an update.". Cell Res. 15 (4): 228-36. doi:10.1038/sj.cr.7290291. PMID 15857577.
Lodygin D, Hermeking H (2005). "The role of epigenetic inactivation of 14-3-3sigma in human cancer.". Cell Res. 15 (4): 237-46. doi:10.1038/sj.cr.7290292. PMID 15857578.
Rasmussen HH, van Damme J, Puype M, et al. (1993). "Microsequences of 145 proteins recorded in the two-dimensional gel protein database of normal human epidermal keratinocytes.". Electrophoresis 13 (12): 960-9. PMID 1286667.
Prasad GL, Valverius EM, McDuffie E, Cooper HL (1992). "Complementary DNA cloning of a novel epithelial cell marker protein, HME1, that may be down-regulated in neoplastic mammary cells.". Cell Growth Differ. 3 (8): 507-13. PMID 1390337.
Leffers H, Madsen P, Rasmussen HH, et al. (1993). "Molecular cloning and expression of the transformation sensitive epithelial marker stratifin. A member of a protein family that has been involved in the protein kinase C signalling pathway.". J. Mol. Biol. 231 (4): 982-98. doi:10.1006/jmbi.1993.1346. PMID 8515476.
Hermeking H, Lengauer C, Polyak K, et al. (1998). "14-3-3 sigma is a p53-regulated inhibitor of G2/M progression.". Mol. Cell 1 (1): 3-11. PMID 9659898.
Chan TA, Hermeking H, Lengauer C, et al. (1999). "14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage.". Nature 401 (6753): 616-20. doi:10.1038/44188. PMID 10524633.
Laronga C, Yang HY, Neal C, Lee MH (2000). "Association of the cyclin-dependent kinases and 14-3-3 sigma negatively regulates cell cycle progression.". J. Biol. Chem. 275 (30): 23106-12. doi:10.1074/jbc.M905616199. PMID 10767298.
Samuel T, Weber HO, Rauch P, et al. (2002). "The G2/M regulator 14-3-3sigma prevents apoptosis through sequestration of Bax.". J. Biol. Chem. 276 (48): 45201-6. doi:10.1074/jbc.M106427200. PMID 11574543.
Johnson BA, Stehn JR, Yaffe MB, Blackwell TK (2002). "Cytoplasmic localization of tristetraprolin involves 14-3-3-dependent and -independent mechanisms.". J. Biol. Chem. 277 (20): 18029-36. doi:10.1074/jbc.M110465200. PMID 11886850.
Tian H, Faje AT, Lee SL, Jorgensen TJ (2002). "Radiation-induced phosphorylation of Chk1 at S345 is associated with p53-dependent cell cycle arrest pathways.". Neoplasia 4 (2): 171-80. doi:10.1038/sj/neo/7900219. PMID 11896572.
Ku NO, Michie S, Resurreccion EZ, et al. (2002). "Keratin binding to 14-3-3 proteins modulates keratin filaments and hepatocyte mitotic progression.". Proc. Natl. Acad. Sci. U.S.A. 99 (7): 4373-8. doi:10.1073/pnas.072624299. PMID 11917136.
Urano T, Saito T, Tsukui T, et al. (2002). "Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth.". Nature 417 (6891): 871-5. doi:10.1038/nature00826. PMID 12075357.
Liu MY, Cai S, Espejo A, et al. (2002). "14-3-3 interacts with the tumor suppressor tuberin at Akt phosphorylation site(s).". Cancer Res. 62 (22): 6475-80. PMID 12438239.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Bhatia K, Siraj AK, Hussain A, et al. (2003). "The tumor suppressor gene 14-3-3 sigma is commonly methylated in normal and malignant lymphoid cells.". Cancer Epidemiol. Biomarkers Prev. 12 (2): 165-9. PMID 12582028.
Kino T, Souvatzoglou E, De Martino MU, et al. (2003). "Protein 14-3-3sigma interacts with and favors cytoplasmic subcellular localization of the glucocorticoid receptor, acting as a negative regulator of the glucocorticoid signaling pathway.". J. Biol. Chem. 278 (28): 25651-6. doi:10.1074/jbc.M302818200. PMID 12730237.
Nakajima T, Shimooka H, Weixa P, et al. (2004). "Immunohistochemical demonstration of 14-3-3 sigma protein in normal human tissues and lung cancers, and the preponderance of its strong expression in epithelial cells of squamous cell lineage.". Pathol. Int. 53 (6): 353-60. PMID 12787309.
Rishi AK, Zhang L, Boyanapalli M, et al. (2003). "Identification and characterization of a cell cycle and apoptosis regulatory protein-1 as a novel mediator of apoptosis signaling by retinoid CD437.". J. Biol. Chem. 278 (35): 33422-35. doi:10.1074/jbc.M303173200. PMID 12816952.