STRAP

From Wikipedia, the free encyclopedia

Serine/threonine kinase receptor associated protein

Identifiers

STRAP; MAWD; PT-WD; UNRIP

External IDs

OMIM: 605986 MGI: 1329037 HomoloGene: 43881

Gene ontology
Molecular Function:	• receptor binding
Cellular Component:	• nucleus • spliceosome
Biological Process:	• negative regulation of transcription from RNA polymerase II promoter • mRNA processing • RNA splicing • negative regulation of transforming growth factor beta receptor signaling pathway

Orthologs

Human

Mouse

n/a

n/a

Refseq

NM_007178 (mRNA)
NP_009109 (protein)

NM_011499 (mRNA)
NP_035629 (protein)

Location

n/a

Chr 6: 137.7 - 137.72 Mb

Pubmed search

[1]

[2]

Serine/threonine kinase receptor associated protein, also known as STRAP, is a human gene.^[1]

[edit] References

^ Entrez Gene: STRAP serine/threonine kinase receptor associated protein.

[edit] Further reading

Datta PK, Chytil A, Gorska AE, Moses HL (1999). "Identification of STRAP, a novel WD domain protein in transforming growth factor-beta signaling.". J. Biol. Chem. 273 (52): 34671-4. PMID 9856985.
Hunt SL, Hsuan JJ, Totty N, Jackson RJ (1999). "unr, a cellular cytoplasmic RNA-binding protein with five cold-shock domains, is required for internal initiation of translation of human rhinovirus RNA.". Genes Dev. 13 (4): 437-48. PMID 10049359.
Matsuda S, Katsumata R, Okuda T, et al. (2000). "Molecular cloning and characterization of human MAWD, a novel protein containing WD-40 repeats frequently overexpressed in breast cancer.". Cancer Res. 60 (1): 13-7. PMID 10646843.
Datta PK, Moses HL (2000). "STRAP and Smad7 synergize in the inhibition of transforming growth factor beta signaling.". Mol. Cell. Biol. 20 (9): 3157-67. PMID 10757800.
Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells.". Genome Res. 10 (10): 1546-60. PMID 11042152.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422-35. doi:10.1101/gr.154701. PMID 11230166.
Iriyama C, Matsuda S, Katsumata R, Hamaguchi M (2001). "Cloning and sequencing of a novel human gene which encodes a putative hydroxylase.". J. Hum. Genet. 46 (5): 289-92. PMID 11355021.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Pillai RS, Grimmler M, Meister G, et al. (2003). "Unique Sm core structure of U7 snRNPs: assembly by a specialized SMN complex and the role of a new component, Lsm11, in histone RNA processing.". Genes Dev. 17 (18): 2321-33. doi:10.1101/gad.274403. PMID 12975319.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Ozdamar B, Bose R, Barrios-Rodiles M, et al. (2005). "Regulation of the polarity protein Par6 by TGFbeta receptors controls epithelial cell plasticity.". Science 307 (5715): 1603-9. doi:10.1126/science.1105718. PMID 15761148.
Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells.". Science 307 (5715): 1621-5. doi:10.1126/science.1105776. PMID 15761153.
Carissimi C, Baccon J, Straccia M, et al. (2005). "Unrip is a component of SMN complexes active in snRNP assembly.". FEBS Lett. 579 (11): 2348-54. doi:10.1016/j.febslet.2005.03.034. PMID 15848170.
Grimmler M, Otter S, Peter C, et al. (2006). "Unrip, a factor implicated in cap-independent translation, associates with the cytosolic SMN complex and influences its intracellular localization.". Hum. Mol. Genet. 14 (20): 3099-111. doi:10.1093/hmg/ddi343. PMID 16159890.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514.
Guo D, Han J, Adam BL, et al. (2005). "Proteomic analysis of SUMO4 substrates in HEK293 cells under serum starvation-induced stress.". Biochem. Biophys. Res. Commun. 337 (4): 1308-18. doi:10.1016/j.bbrc.2005.09.191. PMID 16236267.
Seong HA, Jung H, Choi HS, et al. (2006). "Regulation of transforming growth factor-beta signaling and PDK1 kinase activity by physical interaction between PDK1 and serine-threonine kinase receptor-associated protein.". J. Biol. Chem. 280 (52): 42897-908. doi:10.1074/jbc.M507539200. PMID 16251192.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55-65. doi:10.1101/gr.4039406. PMID 16344560.
Carissimi C, Saieva L, Gabanella F, Pellizzoni L (2007). "Gemin8 is required for the architecture and function of the survival motor neuron complex.". J. Biol. Chem. 281 (48): 37009-16. doi:10.1074/jbc.M607505200. PMID 17023415.
Seong HA, Jung H, Ha H (2007). "NM23-H1 tumor suppressor physically interacts with serine-threonine kinase receptor-associated protein, a transforming growth factor-beta (TGF-beta) receptor-interacting protein, and negatively regulates TGF-beta signaling.". J. Biol. Chem. 282 (16): 12075-96. doi:10.1074/jbc.M609832200. PMID 17314099.