STMN2

From Wikipedia, the free encyclopedia

Stathmin-like 2

Identifiers

STMN2; SCG10; SCGN10; SGC10

External IDs

OMIM: 600621 MGI: 98241 HomoloGene: 5102

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane fraction • soluble fraction • membrane • growth cone
Biological Process:	• intracellular signaling cascade • neuron differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_007029 (mRNA)
NP_008960 (protein)

NM_025285 (mRNA)
NP_079561 (protein)

Location

Chr 8: 80.71 - 80.74 Mb

Chr 3: 8.49 - 8.54 Mb

Pubmed search

[1]

[2]

Stathmin-like 2, also known as STMN2, is a human gene.^[1]

Superior cervical ganglion-10 is a neuronal growth-associated protein which shares significant amino acid sequence similarity with the phosphoprotein stathmin (MIM 151442).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: STMN2 stathmin-like 2.

[edit] Further reading

Okazaki T, Wang H, Masliah E, et al. (1996). "SCG10, a neuron-specific growth-associated protein in Alzheimer's disease.". Neurobiol. Aging 16 (6): 883–94. PMID 8622778.
Di Paolo G, Lutjens R, Pellier V, et al. (1997). "Targeting of SCG10 to the area of the Golgi complex is mediated by its NH2-terminal region.". J. Biol. Chem. 272 (8): 5175–82. PMID 9030585.
Antonsson B, Lütjens R, Di Paolo G, et al. (1997). "Purification, characterization, and in vitro phosphorylation of the neuron-specific membrane-associated protein SCG10.". Protein Expr. Purif. 9 (3): 363–71. doi:10.1006/prep.1996.0710. PMID 9126608.
Antonsson B, Kassel DB, Di Paolo G, et al. (1998). "Identification of in vitro phosphorylation sites in the growth cone protein SCG10. Effect Of phosphorylation site mutants on microtubule-destabilizing activity.". J. Biol. Chem. 273 (14): 8439–46. PMID 9525956.
Lutjens R, Igarashi M, Pellier V, et al. (2000). "Localization and targeting of SCG10 to the trans-Golgi apparatus and growth cone vesicles.". Eur. J. Neurosci. 12 (7): 2224–34. PMID 10947801.
Neidhart S, Antonsson B, Gilliéron C, et al. (2001). "c-Jun N-terminal kinase-3 (JNK3)/stress-activated protein kinase-beta (SAPKbeta) binds and phosphorylates the neuronal microtubule regulator SCG10.". FEBS Lett. 508 (2): 259–64. PMID 11718727.
Nixon AB, Grenningloh G, Casey PJ (2002). "The interaction of RGSZ1 with SCG10 attenuates the ability of SCG10 to promote microtubule disassembly.". J. Biol. Chem. 277 (20): 18127–33. doi:10.1074/jbc.M201065200. PMID 11882662.
Liu Z, Chatterjee TK, Fisher RA (2002). "RGS6 interacts with SCG10 and promotes neuronal differentiation. Role of the G gamma subunit-like (GGL) domain of RGS6.". J. Biol. Chem. 277 (40): 37832–9. doi:10.1074/jbc.M205908200. PMID 12140291.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Greka A, Navarro B, Oancea E, et al. (2003). "TRPC5 is a regulator of hippocampal neurite length and growth cone morphology.". Nat. Neurosci. 6 (8): 837–45. doi:10.1038/nn1092. PMID 12858178.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Kuwabara T, Hsieh J, Nakashima K, et al. (2004). "A small modulatory dsRNA specifies the fate of adult neural stem cells.". Cell 116 (6): 779–93. PMID 15035981.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Gocke CB, Yu H, Kang J (2005). "Systematic identification and analysis of mammalian small ubiquitin-like modifier substrates.". J. Biol. Chem. 280 (6): 5004–12. doi:10.1074/jbc.M411718200. PMID 15561718.
Stelzl U, Worm U, Lalowski M, et al. (2005). "A human protein-protein interaction network: a resource for annotating the proteome.". Cell 122 (6): 957–68. doi:10.1016/j.cell.2005.08.029. PMID 16169070.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Lee HS, Lee DC, Park MH, et al. (2006). "STMN2 is a novel target of beta-catenin/TCF-mediated transcription in human hepatoma cells.". Biochem. Biophys. Res. Commun. 345 (3): 1059–67. doi:10.1016/j.bbrc.2006.05.017. PMID 16712787.
Manna T, Grenningloh G, Miller HP, Wilson L (2007). "Stathmin family protein SCG10 differentially regulates the plus and minus end dynamics of microtubules at steady state in vitro: implications for its role in neurite outgrowth.". Biochemistry 46 (11): 3543–52. doi:10.1021/bi061819d. PMID 17311410.