STK24

From Wikipedia, the free encyclopedia

Serine/threonine kinase 24 (STE20 homolog, yeast)

Identifiers

STK24; STK3; MST-3; MST3; MST3B

External IDs

OMIM: 604984 MGI: 2385007 HomoloGene: 20793

Gene ontology
Molecular Function:	• nucleotide binding • protein serine/threonine kinase activity • protein-tyrosine kinase activity • ATP binding • kinase activity • transferase activity
Biological Process:	• protein amino acid phosphorylation • signal transduction

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001032296 (mRNA)
NP_001027467 (protein)

XM_980463 (mRNA)
XP_985557 (protein)

Location

Chr 13: 97.9 - 98.03 Mb

Chr 14: 120.42 - 120.47 Mb

Pubmed search

[1]

[2]

Serine/threonine kinase 24 (STE20 homolog, yeast), also known as STK24, is a human gene.^[1]

The yeast 'Sterile 20' gene (STE20) functions upstream of the mitogen-activated protein kinase (MAPK) cascade. In mammals, protein kinases related to STE20 can be divided into 2 subfamilies based on their structure and regulation. Members of the PAK subfamily (see PAK3; MIM 300142) contain a C-terminal catalytic domain and an N-terminal regulatory domain that has a CDC42 (MIM 116952)-binding domain. In contrast, members of the GCK subfamily (see MAP4K2; MIM 603166), also called the Sps1 subfamily, have an N-terminal catalytic domain and a C-terminal regulatory domain without a CDC42-binding domain. STK24 belongs to the GCK subfamily of STE20-like kinases (Zhou et al., 2000).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: STK24 serine/threonine kinase 24 (STE20 homolog, yeast).

[edit] Further reading

Schinkmann K, Blenis J (1997). "Cloning and characterization of a human STE20-like protein kinase with unusual cofactor requirements.". J. Biol. Chem. 272 (45): 28695–703. PMID 9353338.
Zhou TH, Ling K, Guo J, et al. (2000). "Identification of a human brain-specific isoform of mammalian STE20-like kinase 3 that is regulated by cAMP-dependent protein kinase.". J. Biol. Chem. 275 (4): 2513–9. PMID 10644707.
Christian SL, McDonough J, Liu Cy CY, et al. (2002). "An evaluation of the assembly of an approximately 15-Mb region on human chromosome 13q32-q33 linked to bipolar disorder and schizophrenia.". Genomics 79 (5): 635–56. doi:10.1006/geno.2002.6765. PMID 11991713.
Huang CY, Wu YM, Hsu CY, et al. (2002). "Caspase activation of mammalian sterile 20-like kinase 3 (Mst3). Nuclear translocation and induction of apoptosis.". J. Biol. Chem. 277 (37): 34367–74. doi:10.1074/jbc.M202468200. PMID 12107159.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Lee WS, Hsu CY, Wang PL, et al. (2004). "Identification and characterization of the nuclear import and export signals of the mammalian Ste20-like protein kinase 3.". FEBS Lett. 572 (1-3): 41–5. doi:10.1016/j.febslet.2004.07.007. PMID 15304321.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514.
Stegert MR, Hergovich A, Tamaskovic R, et al. (2006). "Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3.". Mol. Cell. Biol. 25 (24): 11019–29. doi:10.1128/MCB.25.24.11019-11029.2005. PMID 16314523.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560.
Lu TJ, Lai WY, Huang CY, et al. (2007). "Inhibition of cell migration by autophosphorylated mammalian sterile 20-like kinase 3 (MST3) involves paxillin and protein-tyrosine phosphatase-PEST.". J. Biol. Chem. 281 (50): 38405–17. doi:10.1074/jbc.M605035200. PMID 17046825.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.