STK11

From Wikipedia, the free encyclopedia

Serine/threonine kinase 11

Identifiers

STK11; LKB1; PJS

External IDs

OMIM: 602216 MGI: 1341870 HomoloGene: 393

Gene ontology
Molecular Function:	• nucleotide binding • magnesium ion binding • protein serine/threonine kinase activity • protein binding • ATP binding • transferase activity • manganese ion binding
Cellular Component:	• nucleus • cytoplasm
Biological Process:	• protein amino acid phosphorylation • cell cycle • cell cycle arrest

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_000455 (mRNA)
NP_000446 (protein)

NM_011492 (mRNA)
NP_035622 (protein)

Location

Chr 19: 1.16 - 1.18 Mb

Chr 10: 79.52 - 79.53 Mb

Pubmed search

[1]

[2]

Serine/threonine kinase 11, also known as STK11, is a human gene.

This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.^[1]

[edit] References

^ Entrez Gene: STK11 serine/threonine kinase 11.

[edit] Further reading

Yoo LI, Chung DC, Yuan J (2002). "LKB1--a master tumour suppressor of the small intestine and beyond.". Nat. Rev. Cancer 2 (7): 529–35. doi:10.1038/nrc843. PMID 12094239.
Baas AF, Smit L, Clevers H (2004). "LKB1 tumor suppressor protein: PARtaker in cell polarity.". Trends Cell Biol. 14 (6): 312–9. doi:10.1016/j.tcb.2004.04.001. PMID 15183188.
Katajisto P, Vallenius T, Vaahtomeri K, et al. (2007). "The LKB1 tumor suppressor kinase in human disease.". Biochim. Biophys. Acta 1775 (1): 63–75. doi:10.1016/j.bbcan.2006.08.003. PMID 17010524.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Hemminki A, Tomlinson I, Markie D, et al. (1997). "Localization of a susceptibility locus for Peutz-Jeghers syndrome to 19p using comparative genomic hybridization and targeted linkage analysis.". Nat. Genet. 15 (1): 87–90. doi:10.1038/ng0197-87. PMID 8988175.
Jenne DE, Reimann H, Nezu J, et al. (1998). "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.". Nat. Genet. 18 (1): 38–43. doi:10.1038/ng0198-38. PMID 9425897.
Hemminki A, Markie D, Tomlinson I, et al. (1998). "A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.". Nature 391 (6663): 184–7. doi:10.1038/34432. PMID 9428765.
Bignell GR, Barfoot R, Seal S, et al. (1998). "Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer.". Cancer Res. 58 (7): 1384–6. PMID 9537235.
Nakagawa H, Koyama K, Miyoshi Y, et al. (1998). "Nine novel germline mutations of STK11 in ten families with Peutz-Jeghers syndrome.". Hum. Genet. 103 (2): 168–72. PMID 9760200.
Mehenni H, Gehrig C, Nezu J, et al. (1999). "Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.". Am. J. Hum. Genet. 63 (6): 1641–50. PMID 9837816.
Guldberg P, thor Straten P, Ahrenkiel V, et al. (1999). "Somatic mutation of the Peutz-Jeghers syndrome gene, LKB1/STK11, in malignant melanoma.". Oncogene 18 (9): 1777–80. doi:10.1038/sj.onc.1202486. PMID 10208439.
Su GH, Hruban RH, Bansal RK, et al. (1999). "Germline and somatic mutations of the STK11/LKB1 Peutz-Jeghers gene in pancreatic and biliary cancers.". Am. J. Pathol. 154 (6): 1835–40. PMID 10362809.
Westerman AM, Entius MM, Boor PP, et al. (1999). "Novel mutations in the LKB1/STK11 gene in Dutch Peutz-Jeghers families.". Hum. Mutat. 13 (6): 476–81. doi:10.1002/(SICI)1098-1004(1999)13:6<476::AID-HUMU7>3.0.CO;2-2. PMID 10408777.
Scanlan MJ, Gordan JD, Williamson B, et al. (1999). "Antigens recognized by autologous antibody in patients with renal-cell carcinoma.". Int. J. Cancer 83 (4): 456–64. PMID 10508479.
Collins SP, Reoma JL, Gamm DM, Uhler MD (2000). "LKB1, a novel serine/threonine protein kinase and potential tumour suppressor, is phosphorylated by cAMP-dependent protein kinase (PKA) and prenylated in vivo.". Biochem. J. 345 Pt 3: 673–80. PMID 10642527.
Sapkota GP, Kieloch A, Lizcano JM, et al. (2001). "Phosphorylation of the protein kinase mutated in Peutz-Jeghers cancer syndrome, LKB1/STK11, at Ser431 by p90(RSK) and cAMP-dependent protein kinase, but not its farnesylation at Cys(433), is essential for LKB1 to suppress cell vrowth.". J. Biol. Chem. 276 (22): 19469–82. doi:10.1074/jbc.M009953200. PMID 11297520.
Karuman P, Gozani O, Odze RD, et al. (2001). "The Peutz-Jegher gene product LKB1 is a mediator of p53-dependent cell death.". Mol. Cell 7 (6): 1307–19. PMID 11430832.
Marignani PA, Kanai F, Carpenter CL (2001). "LKB1 associates with Brg1 and is necessary for Brg1-induced growth arrest.". J. Biol. Chem. 276 (35): 32415–8. doi:10.1074/jbc.C100207200. PMID 11445556.
Abed AA, Günther K, Kraus C, et al. (2002). "Mutation screening at the RNA level of the STK11/LKB1 gene in Peutz-Jeghers syndrome reveals complex splicing abnormalities and a novel mRNA isoform (STK11 c.597(insertion mark)598insIVS4).". Hum. Mutat. 18 (5): 397–410. doi:10.1002/humu.1211. PMID 11668633.
Sato N, Rosty C, Jansen M, et al. (2001). "STK11/LKB1 Peutz-Jeghers gene inactivation in intraductal papillary-mucinous neoplasms of the pancreas.". Am. J. Pathol. 159 (6): 2017–22. PMID 11733352.