STIM2

From Wikipedia, the free encyclopedia

Stromal interaction molecule 2

Identifiers

STIM2; FLJ39527; KIAA1482

External IDs

Gene ontology
Molecular Function:	• calcium ion binding • protein binding
Cellular Component:	• endoplasmic reticulum • membrane • integral to membrane • integral to endoplasmic reticulum membrane
Biological Process:	• ion transport • calcium ion transport • negative regulation of calcium ion transport via store-operated calcium channel

Orthologs

Human

Mouse

Refseq

NM_020860 (mRNA)
NP_065911 (protein)

XM_001001195 (mRNA)
XP_001001195 (protein)

Location

Chr 4: 26.47 - 26.64 Mb

Chr 5: 54.29 - 54.41 Mb

Pubmed search

[1]

[2]

Stromal interaction molecule 2, also known as STIM2, is a human gene.^[1]

This gene is a member of the stromal interaction molecule (STIM) family and likely arose, with related family member STIM1, from a common ancestral gene. It encodes a type 1 transmembrane protein whose function is currently unknown, but is a likely adhesion molecule with a role in early hematopoiesis. Alternative translation initiation from an AUG and a non-AUG (UUG) start site results in the production of two different isoforms.^[1]

[edit] References

^ ^a ^b Entrez Gene: STIM2 stromal interaction molecule 2.

[edit] Further reading

Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. PMID 8889548.
Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 7 (2): 143–50. PMID 10819331.
Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs.". Genome Res. 11 (3): 422–35. doi:10.1101/gr.154701. PMID 11230166.
Williams RT, Manji SS, Parker NJ, et al. (2001). "Identification and characterization of the STIM (stromal interaction molecule) gene family: coding for a novel class of transmembrane proteins.". Biochem. J. 357 (Pt 3): 673–85. PMID 11463338.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Colland F, Jacq X, Trouplin V, et al. (2004). "Functional proteomics mapping of a human signaling pathway.". Genome Res. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMID 15231748.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Liou J, Kim ML, Heo WD, et al. (2005). "STIM is a Ca2+ sensor essential for Ca2+-store-depletion-triggered Ca2+ influx.". Curr. Biol. 15 (13): 1235–41. doi:10.1016/j.cub.2005.05.055. PMID 16005298.
Soboloff J, Spassova MA, Hewavitharana T, et al. (2006). "STIM2 is an inhibitor of STIM1-mediated store-operated Ca2+ Entry.". Curr. Biol. 16 (14): 1465–70. doi:10.1016/j.cub.2006.05.051. PMID 16860747.