Sterol O-acyltransferase

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In enzymology, a sterol O-acyltransferase (EC 2.3.1.26) is an enzyme that catalyzes the chemical reaction

acyl-CoA + cholesterol $\rightleftharpoons$ CoA + cholesterol ester

Thus, the two substrates of this enzyme are acyl-CoA and cholesterol, whereas its two products are CoA and cholesterol ester.

This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is acyl-CoA:cholesterol O-acyltransferase. Other names in common use include cholesterol acyltransferase, sterol-ester synthase, sterol-ester synthetase, sterol-ester synthase, acyl coenzyme A-cholesterol-O-acyltransferase, acyl-CoA:cholesterol acyltransferase, ACAT, acylcoenzyme A:cholesterol O-acyltransferase, cholesterol ester synthase, cholesterol ester synthetase, and cholesteryl ester synthetase. This enzyme participates in bile acid biosynthesis.

[edit] References

IUBMB entry for 2.3.1.26
BRENDA references for 2.3.1.26 (Recommended.)
PubMed references for 2.3.1.26
PubMed Central references for 2.3.1.26
Google Scholar references for 2.3.1.26
Sgoutas DS (1970). "Effect of geometry and position of ethylenic bond upon acyl coenzyme A--cholesterol-O-acyltransferase". Biochemistry. 9: 1826–33. doi:10.1021/bi00810a024. PMID 5439042.
Spector AA, Mathur SN, Kaduce TL (1979). "Role of acylcoenzyme A: cholesterol o-acyltransferase in cholesterol metabolism". Prog. Lipid. Res. 18: 31–53. doi:10.1016/0163-7827(79)90003-1. PMID 42927.
Taketani S, Nishino T, Katsuki H (1979). "Characterization of sterol-ester synthetase in Saccharomyces cerevisiae". Biochim. Biophys. Acta. 575: 148–55. PMID 389289.