Sterol 24-C-methyltransferase

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In enzymology, a sterol 24-C-methyltransferase (EC 2.1.1.41) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + 5alpha-cholesta-8,24-dien-3beta-ol $\rightleftharpoons$ S-adenosyl-L-homocysteine + 24-methylene-5alpha-cholest-8-en-3beta-ol

Thus, the two substrates of this enzyme are S-adenosyl methionine and 5alpha-cholesta-8,24-dien-3beta-ol, whereas its two products are S-adenosylhomocysteine and 24-methylene-5alpha-cholest-8-en-3beta-ol.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase. Other names in common use include Delta24-methyltransferase, Delta24-sterol methyltransferase, zymosterol-24-methyltransferase, S-adenosyl-4-methionine:sterol Delta24-methyltransferase, SMT1, 24-sterol C-methyltransferase, S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase, and phytosterol methyltransferase. This enzyme participates in biosynthesis of steroids. It employs one cofactor, glutathione.

[edit] References

IUBMB entry for 2.1.1.41
BRENDA references for 2.1.1.41 (Recommended.)
PubMed references for 2.1.1.41
PubMed Central references for 2.1.1.41
Google Scholar references for 2.1.1.41
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