Steroid sulfotransferase

From Wikipedia, the free encyclopedia

In enzymology, a steroid sulfotransferase (EC 2.8.2.15) is an enzyme that catalyzes the chemical reaction

3'-phosphoadenylyl sulfate + a phenolic steroid adenosine 3',5'-bisphosphate + steroid O-sulfate

Thus, the two substrates of this enzyme are 3'-phosphoadenylyl sulfate and phenolic steroid, whereas its two products are adenosine 3',5'-bisphosphate and steroid O-sulfate.

This enzyme belongs to the family of transferases, specifically the sulfotransferases, which transfer sulfur-containing groups. The systematic name of this enzyme class is 3'-phosphoadenylyl-sulfate:phenolic-steroid sulfotransferase. This enzyme is also called steroid alcohol sulfotransferase. This enzyme participates in androgen and estrogen metabolism.

[edit] References

• IUBMB entry for 2.8.2.15
• BRENDA references for 2.8.2.15 (Recommended.)
• PubMed references for 2.8.2.15
• PubMed Central references for 2.8.2.15
• Google Scholar references for 2.8.2.15
• Adams JB, McDonald D (1980). "Enzymic synthesis of steroid sulphates. XIII. Isolation and properties of dehydroepiandrosterone sulphotransferase from human foetal adrenals". Biochim. Biophys. Acta. 615: 275–8. PMID 6932974. 

[edit] External links

The CAS registry number for this enzyme class is 9032-76-2.

• IUBMB entry for 2.8.2.15

• KEGG entry for 2.8.2.15

• BRENDA entry for 2.8.2.15

• NiceZyme view of 2.8.2.15

• EC2PDB: PDB structures for 2.8.2.15

• PRIAM entry for 2.8.2.15

• PUMA2 entry for 2.8.2.15

• IntEnz: Integrated Enzyme entry for 2.8.2.15

• MetaCyc entry for 2.8.2.15

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050294: steroid sulfotransferase

• AMIGO entry for GO code 0050294: steroid sulfotransferase