Steroid Delta-isomerase

From Wikipedia, the free encyclopedia

In enzymology, a steroid Delta-isomerase (EC 5.3.3.1) is an enzyme that catalyzes the chemical reaction

a 3-oxo-Delta₅-steroid a 3-oxo-Delta₄-steroid

Hence, this enzyme has one substrate, 3-oxo-Delta5-steroid, and one product, 3-oxo-Delta4-steroid.

This enzyme belongs to the family of isomerases, specifically those intramolecular oxidoreductases transposing C=C bonds. The systematic name of this enzyme class is 3-oxosteroid Delta5-Delta4-isomerase. Other names in common use include hydroxysteroid isomerase, steroid isomerase, Delta5-ketosteroid isomerase, Delta5(or Delta4)-3-keto steroid isomerase, Delta5-steroid isomerase, 3-oxosteroid isomerase, Delta5-3-keto steroid isomerase, and Delta5-3-oxosteroid isomerase. This enzyme participates in c21-steroid hormone metabolism and androgen and estrogen metabolism.

Contents 1 Structural studies 2 References 3 External links 3.1 Gene Ontology (GO) codes

[edit] Structural studies

As of late 2007, 25 structures have been solved for this class of enzymes, with PDB accession codes 1BUQ, 1C7H, 1CQS, 1DMM, 1DMN, 1DMQ, 1E97, 1GS3, 1ISK, 1K41, 1OCV, 1OGX, 1OGZ, 1OH0, 1OHO, 1OHP, 1OHS, 1OPY, 1VZZ, 1W00, 1W01, 1W02, 1W6Y, 2PZV, and 8CHO.

[edit] References

• IUBMB entry for 5.3.3.1
• BRENDA references for 5.3.3.1 (Recommended.)
• PubMed references for 5.3.3.1
• PubMed Central references for 5.3.3.1
• Google Scholar references for 5.3.3.1
• Ewald W, Werbin H, Chaikoff IL (1965). "Evidence for the presence of 17-hydroxypregnenedione isomerase in beef adrenal cortex". Biochim. Biophys. Acta. 111: 306–12. PMID 5867327. 
• Kawahara FS and Talalay P (1960). "Crystalline Delta5-3-ketosteroid isomerase". J. Biol. Chem. 235: PC1–PC2. 
• Talalay P and Wang VS (1955). "Enzymic isomerization of Delta5-3-ketosteroids". Biochim. Biophys. Acta 18: 300–301. doi:10.1016/0006-3002(55)90079-2. 

[edit] External links

The CAS registry number for this enzyme class is 9031-36-1.

• IUBMB entry for 5.3.3.1

• KEGG entry for 5.3.3.1

• BRENDA entry for 5.3.3.1

• NiceZyme view of 5.3.3.1

• EC2PDB: PDB structures for 5.3.3.1

• PRIAM entry for 5.3.3.1

• PUMA2 entry for 5.3.3.1

• IntEnz: Integrated Enzyme entry for 5.3.3.1

• MetaCyc entry for 5.3.3.1

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0004769: steroid delta-isomerase

• AMIGO entry for GO code 0004769: steroid delta-isomerase