Stephen Altschul

From Wikipedia, the free encyclopedia

For the former MTV news/current CBS news correspondent, see Serena Altschul.

Stephen Frank Altschul
Stephen Frank Altschul
Born	February 28, 1957
Citizenship	United states
Fields	Bioinformatics
Institutions	NCBI
Known for	BLAST

Stephen Frank Altschul (born February 28, 1957) is an American mathematician who has designed algorithms that are widely used in the field of bioinformatics. Most notably, Altschul is the author of the BLAST algorithm used for sequence analysis of proteins and nucleotides. He graduated summa cum laude^[1] from Harvard University, where he was elected to Phi Beta Kappa in mathematics and has a Ph.D. in the same field of research from Massachusetts Institute of Technology.

[edit] References

• Altschul, Stephen F; Wootton, John C; Gertz, E Michael & Agarwala, Richa (2005), “Protein database searches using compositionally adjusted substitution matrices.”, FEBS J. 272 (20): 5101-9, 2005 Oct, PMID:16218943, doi:10.1111/j.1742-4658.2005.04945.x, <http://www.ncbi.nlm.nih.gov/pubmed/16218943> 
• Altschul, S F; Bundschuh, R; Olsen, R & Hwa, T (2001), “The estimation of statistical parameters for local alignment score distributions.”, Nucleic Acids Res. 29 (2): 351-61, 2001 Jan 15, PMID:11139604, <http://www.ncbi.nlm.nih.gov/pubmed/11139604> 
• Altschul, S F & Koonin, E V (1998), “Iterated profile searches with PSI-BLAST--a tool for discovery in protein databases.”, Trends Biochem. Sci. 23 (11): 444-7, 1998 Nov, PMID:9852764, <http://www.ncbi.nlm.nih.gov/pubmed/9852764> 
• Altschul, S F (1998), “Generalized affine gap costs for protein sequence alignment.”, Proteins 32 (1): 88-96, 1998 Jul 1, PMID:9672045, <http://www.ncbi.nlm.nih.gov/pubmed/9672045> 
• Altschul, S F; Madden, T L; Schäffer, A A & Zhang, J (1997), “Gapped BLAST and PSI-BLAST: a new generation of protein database search programs.”, Nucleic Acids Res. 25 (17): 3389-402, 1997 Sep 1, PMID:9254694, <http://www.ncbi.nlm.nih.gov/pubmed/9254694> 
• Altschul, S F & Gish, W (1996), “Local alignment statistics.”, Meth. Enzymol. 266: 460-80, PMID:8743700, <http://www.ncbi.nlm.nih.gov/pubmed/8743700> 
• Altschul, S F; Boguski, M S; Gish, W & Wootton, J C (1994), “Issues in searching molecular sequence databases.”, Nat. Genet. 6 (2): 119-29, 1994 Feb, PMID:8162065, doi:10.1038/ng0294-119, <http://www.ncbi.nlm.nih.gov/pubmed/8162065> 
• Altschul, S F (1993), “A protein alignment scoring system sensitive at all evolutionary distances.”, J. Mol. Evol. 36 (3): 290-300, 1993 Mar, PMID:8483166, <http://www.ncbi.nlm.nih.gov/pubmed/8483166> 
• Altschul, S F (1991), “Amino acid substitution matrices from an information theoretic perspective.”, J. Mol. Biol. 219 (3): 555-65, 1991 Jun 5, PMID:2051488, <http://www.ncbi.nlm.nih.gov/pubmed/2051488> 
• Altschul, S F & Lipman, D J (1990), “Equal animals.”, Nature 348 (6301): 493-4, 1990 Dec 6, PMID:2247160, doi:10.1038/348493c0, <http://www.ncbi.nlm.nih.gov/pubmed/2247160> 
• Altschul, S F; Gish, W; Miller, W & Myers, E W (1990), “Basic local alignment search tool.”, J. Mol. Biol. 215 (3): 403-10, 1990 Oct 5, PMID:2231712, doi:10.1006/jmbi.1990.9999, <http://www.ncbi.nlm.nih.gov/pubmed/2231712> 
• Altschul, S F & Lipman, D J (1990), “Protein database searches for multiple alignments.”, Proc. Natl. Acad. Sci. U.S.A. 87 (14): 5509-13, 1990 Jul, PMID:2196570, <http://www.ncbi.nlm.nih.gov/pubmed/2196570> 
• Altschul, S F; Carroll, R J & Lipman, D J (1989), “Weights for data related by a tree.”, J. Mol. Biol. 207 (4): 647-53, 1989 Jun 20, PMID:2760928, <http://www.ncbi.nlm.nih.gov/pubmed/2760928> 
• Altschul, S F (1989), “Gap costs for multiple sequence alignment.”, J. Theor. Biol. 138 (3): 297-309, 1989 Jun 8, PMID:2593679, <http://www.ncbi.nlm.nih.gov/pubmed/2593679> 
• Altschul, S F (1989), “Evolutionary trees for the genus Bordetella.”, J. Bacteriol. 171 (2): 1211-3, 1989 Feb, PMID:2536675, <http://www.ncbi.nlm.nih.gov/pubmed/2536675> 
• Altschul, S F & Erickson, B W (1988), “Significance levels for biological sequence comparison using non-linear similarity functions.”, Bull. Math. Biol. 50 (1): 77-92, PMID:3370371, <http://www.ncbi.nlm.nih.gov/pubmed/3370371> 
• Altschul, S F & Erickson, B W (1986), “Locally optimal subalignments using nonlinear similarity functions.”, Bull. Math. Biol. 48 (5-6): 633-60, PMID:3580643, <http://www.ncbi.nlm.nih.gov/pubmed/3580643> 
• Altschul, S F & Erickson, B W (1986), “Optimal sequence alignment using affine gap costs.”, Bull. Math. Biol. 48 (5-6): 603-16, PMID:3580642, <http://www.ncbi.nlm.nih.gov/pubmed/3580642> 
• Altschul, S F & Erickson, B W (1986), “A nonlinear measure of subalignment similarity and its significance levels.”, Bull. Math. Biol. 48 (5-6): 617-32, PMID:3495309, <http://www.ncbi.nlm.nih.gov/pubmed/3495309> 
• Altschul, S F & Erickson, B W (1985), “Significance of nucleotide sequence alignments: a method for random sequence permutation that preserves dinucleotide and codon usage.”, Mol. Biol. Evol. 2 (6): 526-38, 1985 Nov, PMID:3870875, <http://www.ncbi.nlm.nih.gov/pubmed/3870875> 

[edit] External links

• Stephen Altschul at the Mathematics Genealogy Project
• ncbi
• highlycited.com

[edit] References