STEAP2

From Wikipedia, the free encyclopedia

Six transmembrane epithelial antigen of the prostate 2

Identifiers

STEAP2; IPCA1; PCANAP1; PUMPCn; STAMP1; STMP

External IDs

OMIM: 605094 MGI: 1921301 HomoloGene: 17682

Gene ontology
Molecular Function:	• transporter activity • iron ion binding • oxidoreductase activity • FAD binding
Cellular Component:	• early endosome • cytosol • plasma membrane • integral to membrane • trans-Golgi network transport vesicle • integral to Golgi membrane • vesicular fraction
Biological Process:	• electron transport • Golgi to plasma membrane transport • endocytosis • response to hormone stimulus • regulated secretory pathway

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_001040665 (mRNA)
NP_001035755 (protein)

XM_284053 (mRNA)
XP_284053 (protein)

Location

Chr 7: 89.68 - 89.7 Mb

Chr 5: 5.68 - 5.7 Mb

Pubmed search

[1]

[2]

Six transmembrane epithelial antigen of the prostate 2, also known as STEAP2, is a human gene.^[1]

This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.^[1]

[edit] References

^ ^a ^b Entrez Gene: STEAP2 six transmembrane epithelial antigen of the prostate 2.

[edit] Further reading

Denoeud F, Kapranov P, Ucla C, et al. (2007). "Prominent use of distal 5' transcription start sites and discovery of a large number of additional exons in ENCODE regions.". Genome Res. 17 (6): 746-59. doi:10.1101/gr.5660607. PMID 17567994.
Ohgami RS, Campagna DR, McDonald A, Fleming MD (2006). "The Steap proteins are metalloreductases.". Blood 108 (4): 1388-94. doi:10.1182/blood-2006-02-003681. PMID 16609065.
Korkmaz CG, Korkmaz KS, Kurys P, et al. (2005). "Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer.". Oncogene 24 (31): 4934-45. doi:10.1038/sj.onc.1208677. PMID 15897894.
Sanchez-Pulido L, Rojas AM, Valencia A, et al. (2005). "ACRATA: a novel electron transfer domain associated to apoptosis and cancer.". BMC Cancer 4: 98. doi:10.1186/1471-2407-4-98. PMID 15623366.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265-70. doi:10.1101/gr.1293003. PMID 12975309.
Porkka KP, Helenius MA, Visakorpi T (2002). "Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.". Lab. Invest. 82 (11): 1573-82. PMID 12429817.
Korkmaz KS, Elbi C, Korkmaz CG, et al. (2002). "Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer.". J. Biol. Chem. 277 (39): 36689-96. doi:10.1074/jbc.M202414200. PMID 12095985.
Walker MG, Volkmuth W, Sprinzak E, et al. (2000). "Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes.". Genome Res. 9 (12): 1198-203. PMID 10613842.