STCH

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Stress 70 protein chaperone, microsome-associated, 60kDa
Identifiers
Symbol(s) STCH;
External IDs OMIM: 601100 MGI: 1309463 HomoloGene: 5062
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6782 110920
Ensembl ENSG00000155304 ENSMUSG00000032932
Uniprot P48723 Q8BM72
Refseq NM_006948 (mRNA)
NP_008879 (protein)		 NM_030201 (mRNA)
NP_084477 (protein)
Location Chr 21: 14.67 - 14.68 Mb Chr 16: 75.64 - 75.65 Mb
Pubmed search [1] [2]

Stress 70 protein chaperone, microsome-associated, 60kDa, also known as STCH, is a human gene.[1]

The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein.[1]

[edit] References

  1. ^ a b Entrez Gene: STCH stress 70 protein chaperone, microsome-associated, 60kDa.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Otterson GA, Flynn GC, Kratzke RA, et al. (1994). "Stch encodes the 'ATPase core' of a microsomal stress 70 protein.". EMBO J. 13 (5): 1216-25. PMID 8131751. 
  • Brodsky G, Otterson GA, Parry BB, et al. (1997). "Localization of STCH to human chromosome 21q11.1.". Genomics 30 (3): 627-8. doi:10.1006/geno.1995.1291. PMID 8825657. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Hillier LD, Lennon G, Becker M, et al. (1997). "Generation and analysis of 280,000 human expressed sequence tags.". Genome Res. 6 (9): 807-28. PMID 8889549. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Kaye FJ, Modi S, Ivanovska I, et al. (2000). "A family of ubiquitin-like proteins binds the ATPase domain of Hsp70-like Stch.". FEBS Lett. 467 (2-3): 348-55. PMID 10675567. 
  • Hattori M, Fujiyama A, Taylor TD, et al. (2000). "The DNA sequence of human chromosome 21.". Nature 405 (6784): 311-9. doi:10.1038/35012518. PMID 10830953. 
  • Wistow G, Bernstein SL, Wyatt MK, et al. (2002). "Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants.". Mol. Vis. 8: 205-20. PMID 12107410. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Aoki M, Yamamoto K, Ohyama S, et al. (2005). "A genetic variant in the gene encoding the stress70 protein chaperone family member STCH is associated with gastric cancer in the Japanese population.". Biochem. Biophys. Res. Commun. 335 (2): 566-74. doi:10.1016/j.bbrc.2005.07.110. PMID 16087163. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
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