Stanley Fields

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Stanley Fields is an American biologist best known for developing the yeast two hybrid method for identifying protein-protein interactions [1]. He is currently a professor of Genome Sciences at the University of Washington.

Along with Dr. Matt Kaeberlein and Dr. Brian Kennedy, Dr. Fields has carried out genome-wide screens for aging genes in yeast. Dr. Fields has also vocally questioned the hypothesis that lifespan extension from caloric restriction is mediated by Sirtuins [2]. Instead Kaeberlein, Fields, and Kennedy have proposed that caloric restriction increases lifespan by decreasing the activity of the Target or Rapamycin (TOR) kinase [3].

Dr. Fields is a Howard Hughes Medical Institute Investigator.

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[edit] References

  1. ^ Fields, S., and Song, O. (1989). A novel genetic system to detect protein-protein interactions. Nature 340, 245-246.
  2. ^ Kaeberlein, M., Kirkland, K.T., Fields, S., and Kennedy, B.K. (2004). Sir2-independent life span extension by calorie restriction in yeast. PLoS Biol 2, E296.
  3. ^ Kaeberlein, M., Powers, R.W., 3rd, Steffen, K.K., Westman, E.A., Hu, D., Dang, N., Kerr, E.O., Kirkland, K.T., Fields, S., and Kennedy, B.K. (2005). Regulation of yeast replicative life span by TOR and Sch9 in response to nutrients. Science 310, 1193-1196.
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