STAU2

From Wikipedia, the free encyclopedia

Staufen, RNA binding protein, homolog 2 (Drosophila)

PDB rendering based on 1uhz.

Available structures: 1uhz

Identifiers

Symbol(s)

STAU2; 39K2; 39K3; DKFZp781K0371; MGC119606

External IDs

OMIM: 605920 MGI: 1352508 HomoloGene: 8666

Gene ontology
Molecular Function:	• double-stranded RNA binding
Cellular Component:	• intracellular • nucleus • endoplasmic reticulum • microtubule
Biological Process:	• transport

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014393 (mRNA)
NP_055208 (protein)

NM_025303 (mRNA)
NP_079579 (protein)

Location

Chr 8: 74.5 - 74.82 Mb

Chr 1: 16.21 - 16.5 Mb

Pubmed search

[1]

[2]

Staufen, RNA binding protein, homolog 2 (Drosophila), also known as STAU2, is a human gene.^[1]

Staufen homolog 2 is a member of the family of double-stranded RNA (dsRNA)-binding proteins involved in the transport and/or localization of mRNAs to different subcellular compartments and/or organelles. These proteins are characterized by the presence of multiple dsRNA-binding domains which are required to bind RNAs having double-stranded secondary structures. Staufen homolog 2 shares 48.5% and 59.9% similarity with drosophila and human staufen, respectively. The exact function of Staufen homolog 2 is not known, but since it contains 3 copies of conserved dsRNA binding domain, it could be involved in double-stranded RNA binding events.^[1]

[edit] References

^ ^a ^b Entrez Gene: STAU2 staufen, RNA binding protein, homolog 2 (Drosophila).

[edit] Further reading

Kiebler MA, DesGroseillers L (2000). "Molecular insights into mRNA transport and local translation in the mammalian nervous system.". Neuron 25 (1): 19-28. PMID 10707969.
Furic L, Maher-Laporte M, DesGroseillers L (2008). "A genome-wide approach identifies distinct but overlapping subsets of cellular mRNAs associated with Staufen1- and Staufen2-containing ribonucleoprotein complexes.". RNA 14 (2): 324-35. doi:10.1261/rna.720308. PMID 18094122.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285-92. doi:10.1038/nbt1240. PMID 16964243.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334.
Chatel-Chaix L, Clément JF, Martel C, et al. (2004). "Identification of Staufen in the human immunodeficiency virus type 1 Gag ribonucleoprotein complex and a role in generating infectious viral particles.". Mol. Cell. Biol. 24 (7): 2637-48. PMID 15024055.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Duchaîne TF, Hemraj I, Furic L, et al. (2003). "Staufen2 isoforms localize to the somatodendritic domain of neurons and interact with different organelles.". J. Cell. Sci. 115 (Pt 16): 3285-95. PMID 12140260.
Buchner G, Bassi MT, Andolfi G, et al. (2000). "Identification of a novel homolog of the Drosophila staufen protein in the chromosome 8q13-q21.1 region.". Genomics 62 (1): 113-8. doi:10.1006/geno.1999.6015. PMID 10585778.