STAT5A

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Signal transducer and activator of transcription 5A
PDB rendering based on 1y1u.
Available structures: 1y1u
Identifiers
Symbol(s) STAT5A; MGF; STAT5
External IDs OMIM: 601511 MGI103036 HomoloGene20680
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 6776 20850
Ensembl ENSG00000126561 ENSMUSG00000004043
Uniprot P42229 Q3UZ79
Refseq NM_003152 (mRNA)
NP_003143 (protein)
NM_011488 (mRNA)
NP_035618 (protein)
Location Chr 17: 37.69 - 37.72 Mb Chr 11: 100.68 - 100.7 Mb
Pubmed search [1] [2]

Signal transducer and activator of transcription 5A, also known as STAT5A, is a human gene.

The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.[1]

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[edit] References

[edit] Further reading

  • Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges.". Gene 285 (1-2): 1–24. PMID 12039028. 
  • Buitenhuis M, Coffer PJ, Koenderman L (2005). "Signal transducer and activator of transcription 5 (STAT5).". Int. J. Biochem. Cell Biol. 36 (11): 2120–4. doi:10.1016/j.biocel.2003.11.008. PMID 15313458.