STAT2

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Signal transducer and activator of transcription 2, 113kDa
Identifiers
Symbol(s) STAT2; ISGF-3; MGC59816; P113; STAT113
External IDs OMIM: 600556 MGI: 103039 HomoloGene: 3952
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 6773 20847
Ensembl ENSG00000170581 ENSMUSG00000040033
Uniprot P52630 n/a
Refseq NM_005419 (mRNA)
NP_005410 (protein)		 XM_990913 (mRNA)
XP_996007 (protein)
Location Chr 12: 55.02 - 55.04 Mb Chr 10: 127.67 - 127.7 Mb
Pubmed search [1] [2]

Signal transducer and activator of transcription 2, 113kDa, also known as STAT2, is a human gene.[1]

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus.[1]

[edit] References

  1. ^ a b Entrez Gene: STAT2 signal transducer and activator of transcription 2, 113kDa.

[edit] Further reading

  • Cebulla CM, Miller DM, Sedmak DD (2000). "Viral inhibition of interferon signal transduction.". Intervirology 42 (5-6): 325–30. PMID 10702714. 
  • Kisseleva T, Bhattacharya S, Braunstein J, Schindler CW (2002). "Signaling through the JAK/STAT pathway, recent advances and future challenges.". Gene 285 (1-2): 1–24. PMID 12039028. 
  • Fu XY, Schindler C, Improta T, et al. (1992). "The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction.". Proc. Natl. Acad. Sci. U.S.A. 89 (16): 7840–3. PMID 1502204. 
  • Uddin S, Chamdin A, Platanias LC (1995). "Interaction of the transcriptional activator Stat-2 with the type I interferon receptor.". J. Biol. Chem. 270 (42): 24627–30. PMID 7559568. 
  • Marrero MB, Schieffer B, Paxton WG, et al. (1995). "Direct stimulation of Jak/STAT pathway by the angiotensin II AT1 receptor.". Nature 375 (6528): 247–50. doi:10.1038/375247a0. PMID 7746328. 
  • Yan R, Qureshi S, Zhong Z, et al. (1995). "The genomic structure of the STAT genes: multiple exons in coincident sites in Stat1 and Stat2.". Nucleic Acids Res. 23 (3): 459–63. PMID 7885841. 
  • Sugiyama T, Nishio Y, Kishimoto T, Akira S (1996). "Identification of alternative splicing form of Stat2.". FEBS Lett. 381 (3): 191–4. PMID 8601453. 
  • Yan H, Krishnan K, Greenlund AC, et al. (1996). "Phosphorylated interferon-alpha receptor 1 subunit (IFNaR1) acts as a docking site for the latent form of the 113 kDa STAT2 protein.". EMBO J. 15 (5): 1064–74. PMID 8605876. 
  • Gupta S, Yan H, Wong LH, et al. (1996). "The SH2 domains of Stat1 and Stat2 mediate multiple interactions in the transduction of IFN-alpha signals.". EMBO J. 15 (5): 1075–84. PMID 8605877. 
  • Li X, Leung S, Qureshi S, et al. (1996). "Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha.". J. Biol. Chem. 271 (10): 5790–4. PMID 8621447. 
  • Bhattacharya S, Eckner R, Grossman S, et al. (1996). "Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha.". Nature 383 (6598): 344–7. doi:10.1038/383344a0. PMID 8848048. 
  • Horvath CM, Stark GR, Kerr IM, Darnell JE (1997). "Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex.". Mol. Cell. Biol. 16 (12): 6957–64. PMID 8943351. 
  • Bluyssen HA, Levy DE (1997). "Stat2 is a transcriptional activator that requires sequence-specific contacts provided by stat1 and p48 for stable interaction with DNA.". J. Biol. Chem. 272 (7): 4600–5. PMID 9020188. 
  • Li X, Leung S, Kerr IM, Stark GR (1997). "Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling.". Mol. Cell. Biol. 17 (4): 2048–56. PMID 9121453. 
  • Martinez-Moczygemba M, Gutch MJ, French DL, Reich NC (1997). "Distinct STAT structure promotes interaction of STAT2 with the p48 subunit of the interferon-alpha-stimulated transcription factor ISGF3.". J. Biol. Chem. 272 (32): 20070–6. PMID 9242679. 
  • Mowen K, David M (1998). "Role of the STAT1-SH2 domain and STAT2 in the activation and nuclear translocation of STAT1.". J. Biol. Chem. 273 (46): 30073–6. PMID 9804758. 
  • Dumler I, Kopmann A, Wagner K, et al. (1999). "Urokinase induces activation and formation of Stat4 and Stat1-Stat2 complexes in human vascular smooth muscle cells.". J. Biol. Chem. 274 (34): 24059–65. PMID 10446176. 
  • Paulson M, Pisharody S, Pan L, et al. (1999). "Stat protein transactivation domains recruit p300/CBP through widely divergent sequences.". J. Biol. Chem. 274 (36): 25343–9. PMID 10464260. 
  • Gupta S, Jiang M, Pernis AB (1999). "IFN-alpha activates Stat6 and leads to the formation of Stat2:Stat6 complexes in B cells.". J. Immunol. 163 (7): 3834–41. PMID 10490982. 
  • Vila-Coro AJ, Rodríguez-Frade JM, Martín De Ana A, et al. (1999). "The chemokine SDF-1alpha triggers CXCR4 receptor dimerization and activates the JAK/STAT pathway.". FASEB J. 13 (13): 1699–710. PMID 10506573. 
 This article on a gene on chromosome 12 is a stub. You can help Wikipedia by expanding it. 
STAT2 is a STAT protein.

[edit] External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD
v • d • e
Cell signaling: carrier proteins: adaptor proteins
STAT
STAT1 - STAT2 - STAT3 - STAT4 - STAT5 - STAT6
Interferon regulatory factors
Growth factor receptor-bound protein
other