STARD5

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START domain containing 5
Identifiers
Symbol(s) STARD5; MGC10327
External IDs OMIM: 607050 MGI: 2156765 HomoloGene: 11346
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 80765 170460
Ensembl ENSG00000172345 ENSMUSG00000046027
Uniprot Q9NSY2 Q78RK2
Refseq NM_030574 (mRNA)
NP_085051 (protein)		 NM_023377 (mRNA)
NP_075866 (protein)
Location Chr 15: 79.39 - 79.4 Mb Chr 7: 83.51 - 83.52 Mb
Pubmed search [1] [2]

START domain containing 5, also known as STARD5, is a human gene.[1]

Cholesterol homeostasis is regulated, at least in part, by sterol regulatory element (SRE)-binding proteins (e.g., SREBP1; MIM 184756) and by liver X receptors (e.g., LXRA; MIM 602423). Upon sterol depletion, LXRs are inactive and SREBPs are cleaved, after which they bind promoter SREs and activate genes involved in cholesterol biosynthesis and uptake. Sterol transport is mediated by vesicles or by soluble protein carriers, such as steroidogenic acute regulatory protein (STAR; MIM 600617). STAR is homologous to a family of proteins containing a 200- to 210-amino acid STAR-related lipid transfer (START) domain, including STARD5 (Soccio et al., 2002).[supplied by OMIM][1]

[edit] References

  1. ^ a b Entrez Gene: STARD5 START domain containing 5.

[edit] Further reading

  • Strauss JF, Kishida T, Christenson LK, et al. (2004). "START domain proteins and the intracellular trafficking of cholesterol in steroidogenic cells.". Mol. Cell. Endocrinol. 202 (1-2): 59–65. PMID 12770731. 
  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171–4. PMID 8125298. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149–56. PMID 9373149. 
  • Wines ME, Lee L, Katari MS, et al. (2001). "Identification of mesoderm development (mesd) candidate genes by comparative mapping and genome sequence analysis.". Genomics 72 (1): 88–98. doi:10.1006/geno.2000.6466. PMID 11247670. 
  • Soccio RE, Adams RM, Romanowski MJ, et al. (2002). "The cholesterol-regulated StarD4 gene encodes a StAR-related lipid transfer protein with two closely related homologues, StarD5 and StarD6.". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6943–8. doi:10.1073/pnas.052143799. PMID 12011452. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Soccio RE, Adams RM, Maxwell KN, Breslow JL (2005). "Differential gene regulation of StarD4 and StarD5 cholesterol transfer proteins. Activation of StarD4 by sterol regulatory element-binding protein-2 and StarD5 by endoplasmic reticulum stress.". J. Biol. Chem. 280 (19): 19410–8. doi:10.1074/jbc.M501778200. PMID 15760897. 
  • Rodriguez-Agudo D, Ren S, Hylemon PB, et al. (2005). "Human StarD5, a cytosolic StAR-related lipid binding protein.". J. Lipid Res. 46 (8): 1615–23. doi:10.1194/jlr.M400501-JLR200. PMID 15897605. 
  • Rodriguez-Agudo D, Ren S, Hylemon PB, et al. (2006). "Localization of StarD5 cholesterol binding protein.". J. Lipid Res. 47 (6): 1168–75. doi:10.1194/jlr.M500447-JLR200. PMID 16534142. 
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