STAP2

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Signal-transducing adaptor protein-2
Identifiers
Symbol(s) STAP2; BKS; FLJ20234
External IDs OMIM: 607881 MGI: 2147039 HomoloGene: 9798
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 55620 106766
Ensembl ENSG00000178078 ENSMUSG00000038781
Uniprot n/a Q8R0L1
Refseq XM_001130057 (mRNA)
XP_001130057 (protein)		 NM_145934 (mRNA)
NP_666046 (protein)
Location Chr 19: 4.28 - 4.29 Mb Chr 17: 55.59 - 55.6 Mb
Pubmed search [1] [2]

Signal-transducing adaptor protein-2, also known as STAP2, is a human gene.[1]

This gene encodes the substrate of breast tumor kinase, an Src-type non-receptor tyrosine kinase. The encoded protein possesses domains and several tyrosine phosphorylation sites characteristic of adaptor proteins that mediate the interactions linking proteins involved in signal transduction pathways. Alternative splicing results in multiple transcript variants.[1]

[edit] References

  1. ^ a b Entrez Gene: STAP2 signal-transducing adaptor protein-2.

[edit] Further reading

  • Rosenzweig BL, Imamura T, Okadome T, et al. (1995). "Cloning and characterization of a human type II receptor for bone morphogenetic proteins.". Proc. Natl. Acad. Sci. U.S.A. 92 (17): 7632–6. PMID 7644468. 
  • Mitchell PJ, Sara EA, Crompton MR (2000). "A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK.". Oncogene 19 (37): 4273–82. doi:10.1038/sj.onc.1203775. PMID 10980601. 
  • Dehal P, Predki P, Olsen AS, et al. (2001). "Human chromosome 19 and related regions in mouse: conservative and lineage-specific evolution.". Science 293 (5527): 104–11. doi:10.1126/science.1060310. PMID 11441184. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Minoguchi M, Minoguchi S, Aki D, et al. (2003). "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.". J. Biol. Chem. 278 (13): 11182–9. doi:10.1074/jbc.M211230200. PMID 12540842. 
  • Yamamoto T, Yumioka T, Sekine Y, et al. (2003). "Regulation of FcepsilonRI-mediated signaling by an adaptor protein STAP-2/BSK in rat basophilic leukemia RBL-2H3 cells.". Biochem. Biophys. Res. Commun. 306 (3): 767–73. PMID 12810085. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Sekine Y, Yamamoto T, Yumioka T, et al. (2005). "Physical and functional interactions between STAP-2/BKS and STAT5.". J. Biol. Chem. 280 (9): 8188–96. doi:10.1074/jbc.M411692200. PMID 15611091. 
  • Sekine Y, Tsuji S, Ikeda O, et al. (2007). "Signal-transducing adaptor protein-2 regulates integrin-mediated T cell adhesion through protein degradation of focal adhesion kinase.". J. Immunol. 179 (4): 2397–407. PMID 17675501. 
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