STAP1

From Wikipedia, the free encyclopedia

BCR downstream signaling 1

PDB rendering based on 1x1f.

Available structures: 1x1f

Identifiers

Symbol(s)

BRDG1; STAP1

External IDs

OMIM: 604298 MGI: 1926193 HomoloGene: 8103

Gene ontology
Molecular Function:	• SH3/SH2 adaptor activity • protein binding
Biological Process:	• intracellular protein transport • membrane fusion • humoral immune response • transmembrane receptor protein tyrosine kinase signaling pathway • intracellular signaling cascade

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_012108 (mRNA)
NP_036240 (protein)

XM_001003185 (mRNA)
XP_001003185 (protein)

Location

Chr 4: 68.11 - 68.16 Mb

Chr 5: 87.15 - 87.18 Mb

Pubmed search

[1]

[2]

BCR downstream signaling 1, also known as BRDG1, is a human gene.^[1]

The protein encoded by this gene functions as a docking protein acting downstream of Tec tyrosine kinase in B cell antigen receptor signaling. The protein is directly phosphorylated by Tec in vitro where it participates in a postive feedback loop, increasing Tec activity. A mouse ortholog, stem cell adaptor protein 1, shares 83% identity with its human counterpart.^[1]

[edit] References

^ ^a ^b Entrez Gene: BRDG1 BCR downstream signaling 1.

[edit] Further reading

Kurosaki T (1999). "Genetic analysis of B cell antigen receptor signaling.". Annu. Rev. Immunol. 17: 555–92. doi:10.1146/annurev.immunol.17.1.555. PMID 10358768.
Ohya K, Kajigaya S, Kitanaka A, et al. (1999). "Molecular cloning of a docking protein, BRDG1, that acts downstream of the Tec tyrosine kinase.". Proc. Natl. Acad. Sci. U.S.A. 96 (21): 11976–81. PMID 10518561.
Masuhara M, Nagao K, Nishikawa M, et al. (2000). "Molecular cloning of murine STAP-1, the stem-cell-specific adaptor protein containing PH and SH2 domains.". Biochem. Biophys. Res. Commun. 268 (3): 697–703. doi:10.1006/bbrc.2000.2223. PMID 10679268.
Harrington JJ, Sherf B, Rundlett S, et al. (2001). "Creation of genome-wide protein expression libraries using random activation of gene expression.". Nat. Biotechnol. 19 (5): 440–5. doi:10.1038/88107. PMID 11329013.
Yokohari K, Yamashita Y, Okada S, et al. (2002). "Isoform-dependent interaction of BRDG1 with Tec kinase.". Biochem. Biophys. Res. Commun. 289 (2): 414–20. doi:10.1006/bbrc.2001.6008. PMID 11716489.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Minoguchi M, Minoguchi S, Aki D, et al. (2003). "STAP-2/BKS, an adaptor/docking protein, modulates STAT3 activation in acute-phase response through its YXXQ motif.". J. Biol. Chem. 278 (13): 11182–9. doi:10.1074/jbc.M211230200. PMID 12540842.
Gstaiger M, Luke B, Hess D, et al. (2003). "Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI.". Science 302 (5648): 1208–12. doi:10.1126/science.1088401. PMID 14615539.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Ma J, Dempsey AA, Stamatiou D, et al. (2007). "Identifying leukocyte gene expression patterns associated with plasma lipid levels in human subjects.". Atherosclerosis 191 (1): 63–72. doi:10.1016/j.atherosclerosis.2006.05.032. PMID 16806233.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.