STAG1

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Stromal antigen 1
Identifiers
Symbol(s) STAG1; DKFZp781D1416; SA1
External IDs OMIM: 604358 MGI: 1098658 HomoloGene: 21191
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 10274 20842
Ensembl ENSG00000118007 ENSMUSG00000037286
Uniprot Q8WVM7 Q6P5D1
Refseq NM_005862 (mRNA)
NP_005853 (protein)		 XM_977517 (mRNA)
XP_982611 (protein)
Location Chr 3: 137.54 - 137.95 Mb Chr 9: 100.45 - 100.77 Mb
Pubmed search [1] [2]

Stromal antigen 1, also known as STAG1, is a human gene.[1]

This gene is a member of the SCC3 family and is expressed in the nucleus. It encodes a component of cohesin, a multisubunit protein complex that provides sister chromatid cohesion along the length of a chromosome from DNA replication through prophase and prometaphase, after which it is dissociated in preparation for segregation during anaphase.[1]

[edit] References

  1. ^ a b Entrez Gene: STAG1 stromal antigen 1.

[edit] Further reading

  • Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes.". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMID 16344560. 
  • Losada A, Yokochi T, Hirano T (2006). "Functional contribution of Pds5 to cohesin-mediated cohesion in human cells and Xenopus egg extracts.". J. Cell. Sci. 118 (Pt 10): 2133–41. doi:10.1242/jcs.02355. PMID 15855230. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Anazawa Y, Arakawa H, Nakagawa H, Nakamura Y (2004). "Identification of STAG1 as a key mediator of a p53-dependent apoptotic pathway.". Oncogene 23 (46): 7621–7. doi:10.1038/sj.onc.1207270. PMID 15361841. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Prieto I, Pezzi N, Buesa JM, et al. (2003). "STAG2 and Rad21 mammalian mitotic cohesins are implicated in meiosis.". EMBO Rep. 3 (6): 543–50. doi:10.1093/embo-reports/kvf108. PMID 12034751. 
  • Gregson HC, Schmiesing JA, Kim JS, et al. (2002). "A potential role for human cohesin in mitotic spindle aster assembly.". J. Biol. Chem. 276 (50): 47575–82. doi:10.1074/jbc.M103364200. PMID 11590136. 
  • Sumara I, Vorlaufer E, Gieffers C, et al. (2000). "Characterization of vertebrate cohesin complexes and their regulation in prophase.". J. Cell Biol. 151 (4): 749–62. PMID 11076961. 
  • Carramolino L, Lee BC, Zaballos A, et al. (1997). "SA-1, a nuclear protein encoded by one member of a novel gene family: molecular cloning and detection in hemopoietic organs.". Gene 195 (2): 151–9. PMID 9305759. 
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