ST8SIA1

From Wikipedia, the free encyclopedia

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1

Identifiers

ST8SIA1; GD3S; SIAT8; SIAT8A; ST8Sia I; ST8SiaI

External IDs

OMIM: 601123 MGI: 106011 HomoloGene: 2282

Gene ontology
Molecular Function:	• alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity
Cellular Component:	• membrane • integral to membrane • integral to Golgi membrane
Biological Process:	• carbohydrate metabolic process • protein amino acid glycosylation • glycosphingolipid biosynthetic process • positive regulation of cell proliferation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003034 (mRNA)
NP_003025 (protein)

NM_011374 (mRNA)
NP_035504 (protein)

Location

Chr 12: 22.25 - 22.38 Mb

Chr 6: 142.78 - 142.92 Mb

Pubmed search

[1]

[2]

ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1, also known as ST8SIA1, is a human gene.^[1]

Gangliosides are membrane-bound glycosphingolipids containing sialic acid. Ganglioside GD3 is known to be important for cell adhesion and growth of cultured malignant cells. The protein encoded by this gene is a type II membrane protein that catalyzes the transfer of sialic acid from CMP-sialic acid to GM3 to produce gangliosides GD3 and GT3. The encoded protein may be found in the Golgi apparatus and is a member of glycosyltransferase family 29.^[1]

[edit] References

^ ^a ^b Entrez Gene: ST8SIA1 ST8 alpha-N-acetyl-neuraminide alpha-2,8-sialyltransferase 1.

[edit] Further reading

Sasaki K, Watanabe E, Kawashima K, et al. (1993). "Expression cloning of a novel Gal beta (1-3/1-4) GlcNAc alpha 2,3-sialyltransferase using lectin resistance selection.". J. Biol. Chem. 268 (30): 22782–7. PMID 7901202.
Haraguchi M, Yamashiro S, Yamamoto A, et al. (1994). "Isolation of GD3 synthase gene by expression cloning of GM3 alpha-2,8-sialyltransferase cDNA using anti-GD2 monoclonal antibody.". Proc. Natl. Acad. Sci. U.S.A. 91 (22): 10455–9. PMID 7937974.
Nara K, Watanabe Y, Maruyama K, et al. (1994). "Expression cloning of a CMP-NeuAc:NeuAc alpha 2-3Gal beta 1-4Glc beta 1-1'Cer alpha 2,8-sialyltransferase (GD3 synthase) from human melanoma cells.". Proc. Natl. Acad. Sci. U.S.A. 91 (17): 7952–6. PMID 8058740.
Sasaki K, Kurata K, Kojima N, et al. (1994). "Expression cloning of a GM3-specific alpha-2,8-sialyltransferase (GD3 synthase).". J. Biol. Chem. 269 (22): 15950–6. PMID 8195250.
Nakayama J, Fukuda MN, Hirabayashi Y, et al. (1996). "Expression cloning of a human GT3 synthase. GD3 AND GT3 are synthesized by a single enzyme.". J. Biol. Chem. 271 (7): 3684–91. PMID 8631981.
Matsuda Y, Nara K, Watanabe Y, et al. (1996). "Chromosome mapping of the GD3 synthase gene (SIAT8) in human and mouse.". Genomics 32 (1): 137–9. doi:10.1006/geno.1996.0090. PMID 8786103.
De Maria R, Lenti L, Malisan F, et al. (1997). "Requirement for GD3 ganglioside in CD95- and ceramide-induced apoptosis.". Science 277 (5332): 1652–5. PMID 9287216.
Angata K, Suzuki M, McAuliffe J, et al. (2000). "Differential biosynthesis of polysialic acid on neural cell adhesion molecule (NCAM) and oligosaccharide acceptors by three distinct alpha 2,8-sialyltransferases, ST8Sia IV (PST), ST8Sia II (STX), and ST8Sia III.". J. Biol. Chem. 275 (24): 18594–601. doi:10.1074/jbc.M910204199. PMID 10766765.
Zeng G, Gao L, Suetake K, et al. (2002). "Variations in gene expression patterns correlated with phenotype of F-11 tumor cells whose expression of GD3-synthase is suppressed.". Cancer Lett. 178 (1): 91–8. PMID 11849746.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Furukawa K, Horie M, Okutomi K, et al. (2003). "Isolation and functional analysis of the melanoma specific promoter region of human GD3 synthase gene.". Biochim. Biophys. Acta 1627 (2-3): 71–8. PMID 12818424.
Moon SK, Kim HM, Lee YC, Kim CH (2004). "Disialoganglioside (GD3) synthase gene expression suppresses vascular smooth muscle cell responses via the inhibition of ERK1/2 phosphorylation, cell cycle progression, and matrix metalloproteinase-9 expression.". J. Biol. Chem. 279 (32): 33063–70. doi:10.1074/jbc.M313462200. PMID 15175338.
Ha KT, Lee YC, Kim CH (2004). "Overexpression of GD3 synthase induces apoptosis of vascular endothelial ECV304 cells through downregulation of Bcl-2.". FEBS Lett. 568 (1-3): 183–7. doi:10.1016/j.febslet.2004.05.020. PMID 15196944.
Tomassini B, Malisan F, Franchi L, et al. (2005). "Calnexin suppresses GD3 synthase-induced apoptosis.". FASEB J. 18 (13): 1553–5. doi:10.1096/fj.04-1675fje. PMID 15319364.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Teintenier-Lelièvre M, Julien S, Juliant S, et al. (2006). "Molecular cloning and expression of a human hST8Sia VI (alpha2,8-sialyltransferase) responsible for the synthesis of the diSia motif on O-glycosylproteins.". Biochem. J. 392 (Pt 3): 665–74. doi:10.1042/BJ20051120. PMID 16120058.
Kang NY, Kang Y, Kang SK, et al. (2006). "Transcriptional regulation of the human GD3 synthase gene expression in Fas-induced Jurkat T cells: a critical role of transcription factor NF-kappaB in regulated expression.". Glycobiology 16 (5): 375–89. doi:10.1093/glycob/cwj087. PMID 16481330.
Ko K, Furukawa K, Takahashi T, et al. (2006). "Fundamental study of small interfering RNAs for ganglioside GD3 synthase gene as a therapeutic target of lung cancers.". Oncogene 25 (52): 6924–35. doi:10.1038/sj.onc.1209683. PMID 16862187.