ST6GALNAC6

From Wikipedia, the free encyclopedia

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

Identifiers

ST6GALNAC6; RP11-203J24.3; SIAT7F; ST6GALNACVI

External IDs

OMIM: 610135 MGI: 1355316 HomoloGene: 8390

Gene ontology
Molecular Function:	• sialyltransferase activity
Cellular Component:	• plasma membrane • integral to membrane • integral to Golgi membrane
Biological Process:	• carbohydrate metabolic process • protein amino acid glycosylation • glycosphingolipid biosynthetic process

Orthologs

Human

Mouse

n/a

Refseq

NM_013443 (mRNA)
NP_038471 (protein)

NM_001025310 (mRNA)
NP_001020481 (protein)

Location

Chr 9: 129.69 - 129.7 Mb

n/a

Pubmed search

[1]

[2]

ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6, also known as ST6GALNAC6, is a human gene.^[1]

[edit] References

^ Entrez Gene: ST6GALNAC6 ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6.

[edit] Further reading

Senda M, Ito A, Tsuchida A, et al. (2007). "Identification and expression of a sialyltransferase responsible for the synthesis of disialylgalactosylgloboside in normal and malignant kidney cells: downregulation of ST6GalNAc VI in renal cancers.". Biochem. J. 402 (3): 459–70. doi:10.1042/BJ20061118. PMID 17123352.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Harduin-Lepers A, Mollicone R, Delannoy P, Oriol R (2005). "The animal sialyltransferases and sialyltransferase-related genes: a phylogenetic approach.". Glycobiology 15 (8): 805–17. doi:10.1093/glycob/cwi063. PMID 15843597.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Tsuchida A, Okajima T, Furukawa K, et al. (2003). "Synthesis of disialyl Lewis a (Le(a)) structure in colon cancer cell lines by a sialyltransferase, ST6GalNAc VI, responsible for the synthesis of alpha-series gangliosides.". J. Biol. Chem. 278 (25): 22787–94. doi:10.1074/jbc.M211034200. PMID 12668675.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Okajima T, Chen HH, Ito H, et al. (2000). "Molecular cloning and expression of mouse GD1alpha/GT1aalpha/GQ1balpha synthase (ST6GalNAc VI) gene.". J. Biol. Chem. 275 (10): 6717–23. PMID 10702226.