SRPRB

From Wikipedia, the free encyclopedia

Signal recognition particle receptor, B subunit

PDB rendering based on 2fh5.

Available structures: 2fh5, 2go5

Identifiers

Symbol(s)

SRPRB; APMCF1

External IDs

MGI: 102964 HomoloGene: 6332

Gene ontology
Molecular Function:	• nucleotide binding • receptor activity • GTP binding
Cellular Component:	• endoplasmic reticulum • signal recognition particle, endoplasmic reticulum targeting • membrane • integral to membrane • ribonucleoprotein complex

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021203 (mRNA)
NP_067026 (protein)

XM_979501 (mRNA)
XP_984595 (protein)

Location

Chr 3: 135.01 - 135.02 Mb

Chr 9: 103.05 - 103.06 Mb

Pubmed search

[1]

[2]

Signal recognition particle receptor, B subunit, also known as SRPRB, is a human gene.^[1]

The protein encoded by this gene has similarity to mouse protein which is a subunit of the signal recognition particle receptor (SR). This subunit is a transmembrane GTPase belonging to the GTPase superfamily. It anchors alpha subunit, a peripheral membrane GTPase, to the ER membrane. SR is required for the cotranslational targeting of both secretory and membrane proteins to the ER membrane.^[1]

[edit] References

^ ^a ^b Entrez Gene: SRPRB signal recognition particle receptor, B subunit.

[edit] Further reading

Miller JD, Tajima S, Lauffer L, Walter P (1995). "The beta subunit of the signal recognition particle receptor is a transmembrane GTPase that anchors the alpha subunit, a peripheral membrane GTPase, to the endoplasmic reticulum membrane.". J. Cell Biol. 128 (3): 273–82. PMID 7844142.
Bacher G, Pool M, Dobberstein B (1999). "The ribosome regulates the GTPase of the beta-subunit of the signal recognition particle receptor.". J. Cell Biol. 146 (4): 723–30. PMID 10459008.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Yan W, Wang WL, Zhu F, et al. (2003). "Isolation of a novel member of small G protein superfamily and its expression in colon cancer.". World J. Gastroenterol. 9 (8): 1719–24. PMID 12918107.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97–105. doi:10.1038/ncb1086. PMID 14743216.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries.". DNA Res. 12 (2): 117–26. doi:10.1093/dnares/12.2.117. PMID 16303743.
Li Q, Yan W, Cheng S, et al. (2007). "Introduction of G1 phase arrest in Human Hepatocellular carcinoma cells (HHCC) by APMCF1 gene transfection through the down-regulation of TIMP3 and up-regulation of the CDK inhibitors p21.". Mol. Biol. Rep. 33 (4): 257–63. doi:10.1007/s11033-006-9007-9. PMID 17080297.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry.". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134. PMID 17353931.