SREBF2

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Sterol regulatory element binding transcription factor 2
PDB rendering based on 1ukl.
Available structures: 1ukl
Identifiers
Symbol(s) SREBF2; SREBP2
External IDs OMIM: 600481 MGI: 107585 HomoloGene: 20966
Orthologs
Human Mouse
Entrez 6721 20788
Ensembl ENSG00000198911 ENSMUSG00000022463
Uniprot Q12772 n/a
Refseq NM_004599 (mRNA)
NP_004590 (protein)		 NM_033218 (mRNA)
NP_150087 (protein)
Location Chr 22: 40.56 - 40.63 Mb Chr 15: 81.97 - 82.03 Mb
Pubmed search [1] [2]

Sterol regulatory element binding transcription factor 2, also known as SREBF2, is a human gene.

This gene encodes a ubiquitously expressed transcription factor that controls cholesterol homeostasis by stimulating transcription of sterol-regulated genes. The encoded protein contains a basic helix-loop-helix-leucine zipper (bHLH-Zip) domain.[1]

Contents

[edit] See also

[edit] References

  1. ^ Entrez Gene: SREBF2 sterol regulatory element binding transcription factor 2.

[edit] Further reading

  • Osborne TF (2001). "CREating a SCAP-less liver keeps SREBPs pinned in the ER membrane and prevents increased lipid synthesis in response to low cholesterol and high insulin.". Genes Dev. 15 (15): 1873–8. doi:10.1101/gad.916601. PMID 11485982. 
  • Szolkiewicz M, Chmielewski M, Nogalska A, et al. (2007). "The potential role of sterol regulatory element binding protein transcription factors in renal injury.". Journal of renal nutrition : the official journal of the Council on Renal Nutrition of the National Kidney Foundation 17 (1): 62–5. doi:10.1053/j.jrn.2006.10.009. PMID 17198935. 
  • Hua X, Wu J, Goldstein JL, et al. (1995). "Structure of the human gene encoding sterol regulatory element binding protein-1 (SREBF1) and localization of SREBF1 and SREBF2 to chromosomes 17p11.2 and 22q13.". Genomics 25 (3): 667–73. PMID 7759101. 
  • Hua X, Yokoyama C, Wu J, et al. (1994). "SREBP-2, a second basic-helix-loop-helix-leucine zipper protein that stimulates transcription by binding to a sterol regulatory element.". Proc. Natl. Acad. Sci. U.S.A. 90 (24): 11603–7. PMID 7903453. 
  • Yokoyama C, Wang X, Briggs MR, et al. (1993). "SREBP-1, a basic-helix-loop-helix-leucine zipper protein that controls transcription of the low density lipoprotein receptor gene.". Cell 75 (1): 187–97. PMID 8402897. 
  • Wang X, Zelenski NG, Yang J, et al. (1996). "Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis.". EMBO J. 15 (5): 1012–20. PMID 8605870. 
  • Hua X, Sakai J, Brown MS, Goldstein JL (1996). "Regulated cleavage of sterol regulatory element binding proteins requires sequences on both sides of the endoplasmic reticulum membrane.". J. Biol. Chem. 271 (17): 10379–84. PMID 8626610. 
  • Pai JT, Brown MS, Goldstein JL (1996). "Purification and cDNA cloning of a second apoptosis-related cysteine protease that cleaves and activates sterol regulatory element binding proteins.". Proc. Natl. Acad. Sci. U.S.A. 93 (11): 5437–42. PMID 8643593. 
  • Sato R, Inoue J, Kawabe Y, et al. (1996). "Sterol-dependent transcriptional regulation of sterol regulatory element-binding protein-2.". J. Biol. Chem. 271 (43): 26461–4. PMID 8900111. 
  • Oliner JD, Andresen JM, Hansen SK, et al. (1996). "SREBP transcriptional activity is mediated through an interaction with the CREB-binding protein.". Genes Dev. 10 (22): 2903–11. PMID 8918891. 
  • Miserez AR, Cao G, Probst LC, Hobbs HH (1997). "Structure of the human gene encoding sterol regulatory element binding protein 2 (SREBF2).". Genomics 40 (1): 31–40. doi:10.1006/geno.1996.4525. PMID 9070916. 
  • Duncan EA, Brown MS, Goldstein JL, Sakai J (1997). "Cleavage site for sterol-regulated protease localized to a leu-Ser bond in the lumenal loop of sterol regulatory element-binding protein-2.". J. Biol. Chem. 272 (19): 12778–85. PMID 9139737. 
  • Harris IR, Farrell AM, Holleran WM, et al. (1998). "Parallel regulation of sterol regulatory element binding protein-2 and the enzymes of cholesterol and fatty acid synthesis but not ceramide synthesis in cultured human keratinocytes and murine epidermis.". J. Lipid Res. 39 (2): 412–22. PMID 9508001. 
  • Kan HY, Pissios P, Chambaz J, Zannis VI (1999). "DNA binding specificity and transactivation properties of SREBP-2 bound to multiple sites on the human apoA-II promoter.". Nucleic Acids Res. 27 (4): 1104–17. PMID 9927745. 
  • Seidah NG, Mowla SJ, Hamelin J, et al. (1999). "Mammalian subtilisin/kexin isozyme SKI-1: A widely expressed proprotein convertase with a unique cleavage specificity and cellular localization.". Proc. Natl. Acad. Sci. U.S.A. 96 (4): 1321–6. PMID 9990022. 
  • Nagoshi E, Imamoto N, Sato R, Yoneda Y (1999). "Nuclear import of sterol regulatory element-binding protein-2, a basic helix-loop-helix-leucine zipper (bHLH-Zip)-containing transcription factor, occurs through the direct interaction of importin beta with HLH-Zip.". Mol. Biol. Cell 10 (7): 2221–33. PMID 10397761. 
  • Dunham I, Shimizu N, Roe BA, et al. (1999). "The DNA sequence of human chromosome 22.". Nature 402 (6761): 489–95. doi:10.1038/990031. PMID 10591208. 
  • DeBose-Boyd RA, Brown MS, Li WP, et al. (2000). "Transport-dependent proteolysis of SREBP: relocation of site-1 protease from Golgi to ER obviates the need for SREBP transport to Golgi.". Cell 99 (7): 703–12. PMID 10619424. 
  • Kotzka J, Müller-Wieland D, Roth G, et al. (2000). "Sterol regulatory element binding proteins (SREBP)-1a and SREBP-2 are linked to the MAP-kinase cascade.". J. Lipid Res. 41 (1): 99–108. PMID 10627507. 
  • Yang T, Goldstein JL, Brown MS (2000). "Overexpression of membrane domain of SCAP prevents sterols from inhibiting SCAP.SREBP exit from endoplasmic reticulum.". J. Biol. Chem. 275 (38): 29881–6. doi:10.1074/jbc.M005439200. PMID 10896675. 

[edit] External links


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v • d • e
Transcription factors and intracellular receptors
(1) Basic domains
(1.1) Basic leucine zipper (bZIP)
Activating transcription factor (AATF, 1, 2, 3, 4, 5, 6, 7) • AP-1 (c-Fos, FOSB, FOSL1, FOSL2, c-Jun, JUNB, JUND) • BACH (1, 2) • BATF • BLZF1 • C/EBP (α, β, γ, δ, ε, ζ) • CREB (1, 3, L1) • CREM • DBP • DDIT3 • GABPA • HLF • MAF (B, F, G, K) • NFE (2, L1, L2) • NRL • NRF1 • XBP1
(1.2) Basic helix-loop-helix (bHLH)
ATOH1 • AhR • AHRR • ARNT • ASCL1 • BHLHB2 • BMAL (ARNTL, ARNTL2) • CLOCK • EPAS1 • HAND (1, 2) • HES (5, 6) • HEY (1, 2, L) • HES1 • HIF (1A, 3A) • ID (1, 2, 3, 4) • LYL1 • MXD4 • MYCL1 • MYCN • Myogenic regulatory factors (MyoD, Myogenin, MYF5, MYF6) • Neurogenins • NeuroD (1, 2) • NPAS (1, 2, 3) • OLIG (1, 2) • Scleraxis • TAL1 • Twist • USF1
(1.3) bHLH-ZIP
MAX • MITF • MNT • MLX • MXI1 • Myc • SREBP (1, 2)
(1.6) Basic helix-span-helix (bHSH)
(2) Zinc finger
DNA-binding domains
(2.1) Nuclear receptor (Cys4)
subfamily 1 (Thyroid hormone (α, β), CAR, FXR, LXR (α, β), PPAR (α, β/δ, γ), PXR, RAR (α, β, γ), ROR (α, β, γ), Rev-ErbA (α, β), VDR) • subfamily 2 (COUP-TF (I, II), Ear-2, HNF4 (α, γ), PNR, RXR (α, β, γ), Testicular receptor (2, 4), TLX) • subfamily 3 (Steroid hormone (Estrogen (α, β), Estrogen related (α, β, γ), Androgen, Glucocorticoid, Mineralocorticoid, Progesterone)) • subfamily 4 NUR (NGFIB, NOR1, NURR1) • subfamily 5 (LRH-1, SF1) • subfamily 6 (GCNF) • subfamily 0 (DAX1, SHP)
(2.2) Other Cys4
GATA (1, 2, 3, 4, 5, 6) • MTA (1, 2, 3)
(2.3) Cys2His2
ATBF1 • BCL(6, 11A, 11B) • CTCF • E4F1 • EGR (2, 3) • ERV3 • General transcription factors (TFIIA, TFIIB, TFIID, TFIIE, TFIIF: 1, 2, TFIIH: 1, 2, 4, 2I, 3A, 3C1, 3C2) • GFI1 • GLI-Krüppel family (1, 2, 3, YY1) • HIC (1, 2) • HIVEP (1, 2, 3) • IKZF (1, 2, 3) • ILF (2, 3) • KLF (2, 4, 5, 6, 9, 10, 11, 12, 13) • MTF1 • MYT1 • OSR1 • Sp1 • zinc finger ((3, 7, 9, 10, 19, 22, 24, 33B, 34, 35, 41, 43, 44, 51, 74, 143, 146, 148, 165, 202, 217, 219, 238, 239, 259, 267, 268, 281, 295, 318, 330, 346, 350, 365, 366, 384, 451, 452, 471, 593, 638, 649, 655) • Zbtb7 (7A) • ZBT (16, 17, 33)
(2.4) Cys6
(2.5) Alternating composition
AIRE • DIDO1 • GRLF1 • ING (1, 2, 4) • JARID (1A, 1B, 1C, 1D, 2) • JMJD1B
(3) Helix-turn-helix
domains
ARX • CDX (1, 2) • CRX • CUTL1 • DLX (3, 4, 5) • EMX2 • EN (1, 2) • FHL (1, 2, 3) • HESX1 • HHEX • HLX • Homeobox (A1, A3, A4, A5, A7, A9, A10, A11, A13, B1, B2, B3, B4, B5, B6, B7, B8, B9, B13, C4, C5, C6, C8, C9, C10, C11, C13, D1, D3, D4, D8, D9, D10, D11, D12, D13) • HOPX • MEIS (1, 2) • MEOX2 • MNX1 • MSX (1, 2) • NANOG • NKX (2-1, 2-5, 3-1) • PHF (3, 6, 10, 17) • POU domain (PIT-1, BRN-3: 1, 2, Octamer transcription factor: 1, 2, 3/4, 6, 7) • OTX (1, 2) • PDX1
(3.2) Paired box
PAX (1, 2, 3, 4, 5, 6, 7, 8, 9)
E2F (1, 2, 3, 4, 5) • FOX proteins (C1, C2, E1, G1, H1, K2, L2, M1, N3, O1A, , O3A, O4, P1, P2, P3)
HSF (1, 2, 4)
(3.5) Tryptophan clusters
ELF (4, 5) • EGF • ELK (1, 3, 4) • ERF • ERG • ETS (1, 2) • ETV (1, 4, 5, 6) • FLI1 • Interferon regulatory factors (1, 2, 3, 4, 5, 6, 7, 8) • MYB • MYBL2
(3.6) TEA domain
transcriptional enhancer factor 1, 2
(4) β-Scaffold factors with
minor groove contacts
(4.1) Rel homology region
NF-κB (NFKB1, NFKB2, REL, RELA, RELB) • NFAT (C1, C2, C3, C4, 5)
(4.2) STAT
STAT (1, 2, 3, 4, 5, 6)
(4.3) p53
(4.4) MADS box
Mef2 (A, B, C, D) • SRF
HNF (1A, 1B) • LEF1 • SOX (2, 3, 4, 5, 6, 8, 9, 10, 11, 13, 15, 18) • SRY • SSRP1
(4.10) Cold-shock domain
(4.11) Runt
(0) Other
transcription factors
(0.2) HMGI(Y)
HMGA (1, 2) • HBP1
Rb • RBL1 • RBL2
(0.5) AP-2/EREBP-related factors
Apetala 2 • EREBP • B3
(0.6) Miscellaneous
ARID (1A, 1B, 2, 3A, 3B, 4A) • CAP • IFI (16, 35) • MLL (2, 3, T1) • MNDA • NFI (A, B, C, X) • NFY (A, B, C) • Rho/Sigma • R-SMAD