SRD5A1

From Wikipedia, the free encyclopedia

Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)

Identifiers

Symbol(s)

SRD5A1;

External IDs

OMIM: 184753 MGI: 98400 HomoloGene: 37426

EC number

1.3.99.5

Gene ontology
Molecular Function:	• 3-oxo-5-alpha-steroid 4-dehydrogenase activity • electron carrier activity
Cellular Component:	• endoplasmic reticulum • microsome • membrane • integral to membrane
Biological Process:	• androgen biosynthetic process • cell-cell signaling • sex determination • sex differentiation • cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

n/a

Refseq

NM_001047 (mRNA)
NP_001038 (protein)

NM_175283 (mRNA)
NP_780492 (protein)

Location

Chr 5: 6.69 - 6.72 Mb

Chr 13: 70.04 - 70.08 Mb

Pubmed search

[1]

[2]

Steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1), also known as SRD5A1, is a human gene.

Steroid 5-alpha-reductase (EC 1.3.99.5) catalyzes the conversion of testosterone into the more potent androgen, dihydrotestosterone (DHT). There are 2 isoforms of the enzyme: SRD5A1 and SRD5A2 (MIM 607306).[supplied by OMIM]^[1]

[edit] See also

5-alpha reductase

[edit] References

^ Entrez Gene: SRD5A1 steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1).

[edit] Further reading

Jenkins EP, Andersson S, Imperato-McGinley J, et al. (1992). "Genetic and pharmacological evidence for more than one human steroid 5 alpha-reductase.". J. Clin. Invest. 89 (1): 293–300. PMID 1345916.
Jenkins EP, Hsieh CL, Milatovich A, et al. (1992). "Characterization and chromosomal mapping of a human steroid 5 alpha-reductase gene and pseudogene and mapping of the mouse homologue.". Genomics 11 (4): 1102–12. PMID 1686016.
Andersson S, Russell DW (1990). "Structural and biochemical properties of cloned and expressed human and rat steroid 5 alpha-reductases.". Proc. Natl. Acad. Sci. U.S.A. 87 (10): 3640–4. PMID 2339109.
Moore RJ, Wilson JD (1972). "Localization of the reduced nicotinamide adenine dinucleotide phosphate: 4 -3-ketosteroid 5 -oxidoreductase in the nuclear membrane of the rat ventral prostate.". J. Biol. Chem. 247 (3): 958–67. PMID 4400474.
Milewich L, Kaimal V, Toews GB (1983). "Androstenedione metabolism in human alveolar macrophages.". J. Clin. Endocrinol. Metab. 56 (5): 920–4. PMID 6833469.
Thigpen AE, Silver RI, Guileyardo JM, et al. (1993). "Tissue distribution and ontogeny of steroid 5 alpha-reductase isozyme expression.". J. Clin. Invest. 92 (2): 903–10. PMID 7688765.
Antonipillai I, Wahe M, Yamamoto J, Horton R (1995). "Activin and inhibin have opposite effects on steroid 5 alpha-reductase activity in genital skin fibroblasts.". Mol. Cell. Endocrinol. 107 (1): 99–104. PMID 7796940.
Hirsch KS, Jones CD, Audia JE, et al. (1993). "LY191704: a selective, nonsteroidal inhibitor of human steroid 5 alpha-reductase type 1.". Proc. Natl. Acad. Sci. U.S.A. 90 (11): 5277–81. PMID 8389478.
Andersson B, Wentland MA, Ricafrente JY, et al. (1996). "A "double adaptor" method for improved shotgun library construction.". Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
Bonkhoff H, Stein U, Aumüller G, Remberger K (1996). "Differential expression of 5 alpha-reductase isoenzymes in the human prostate and prostatic carcinomas.". Prostate 29 (4): 261–7. doi:10.1002/(SICI)1097-0045(199610)29:4<261::AID-PROS7>3.0.CO;2-E. PMID 8876709.
Yu W, Andersson B, Worley KC, et al. (1997). "Large-scale concatenation cDNA sequencing.". Genome Res. 7 (4): 353–8. PMID 9110174.
Ellis JA, Stebbing M, Harrap SB (1998). "Genetic analysis of male pattern baldness and the 5alpha-reductase genes.". J. Invest. Dermatol. 110 (6): 849–53. doi:10.1046/j.1523-1747.1998.00224.x. PMID 9620288.
Zhou Z, Shackleton CH, Pahwa S, et al. (1998). "Prominent sex steroid metabolism in human lymphocytes.". Mol. Cell. Endocrinol. 138 (1-2): 61–9. PMID 9685215.
Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning.". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. doi:10.1073/pnas.160270997. PMID 10931946.
Eminović I, Liović M, Prezelj J, et al. (2002). "New steroid 5alpha-reductase type I (SRD5A1) homologous sequences on human chromosomes 6 and 8.". Pflugers Arch. 442 (6 Suppl 1): R187–9. PMID 11678334.
Ellis JA, Wong ZY, Stebbing M, Harrap SB (2002). "Sex, genes and blood pressure.". Clin. Exp. Pharmacol. Physiol. 28 (12): 1053–5. PMID 11903314.
Rodríguez-Dorantes M, Lizano-Soberón M, Camacho-Arroyo I, et al. (2002). "Evidence that steroid 5alpha-reductase isozyme genes are differentially methylated in human lymphocytes.". J. Steroid Biochem. Mol. Biol. 80 (3): 323–30. PMID 11948017.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Ha SJ, Kim JS, Myung JW, et al. (2003). "Analysis of genetic polymorphisms of steroid 5alpha-reductase type 1 and 2 genes in Korean men with androgenetic alopecia.". J. Dermatol. Sci. 31 (2): 135–41. PMID 12670724.
Habib FK, Ross M, Bayne CW, et al. (2004). "The loss of 5alpha-reductase type I and type II mRNA expression in metastatic prostate cancer to bone and lymph node metastasis.". Clin. Cancer Res. 9 (5): 1815–9. PMID 12738739.