From Wikipedia, the free encyclopedia
| SraD RNA |
 |
| Type: |
Gene; sRNA; |
| 2° structure: |
Predicted; PFOLD |
| Seed alignment: |
Bateman A |
| Avg length: |
75.5 nucleotides |
| Avg identity: |
87% |
|
The SraD RNA (also known as MicA) is a small non-coding RNA that was discovered in E. coli during a large scale screen.[1] Expression of SraD is highly abundant in stationary phase, but low levels could be detected in exponentially growing cells as well. This RNA binds the Hfq protein and regulates levels of gene expression by an antisense mechanism. It is known to target the OmpA gene in E. coli and occludes the ribosome binding site.[2] Under conditions of envelope stress, micA transcription is induced. MicA transcription is under the control of the sigma factor sigma(E).[3]
MicA and RybB transcription is strictly dependent on the bacterial Sigma factor, sigmaE [4].
[edit] References
- ^ Argaman, L; Hershberg R, Vogel J, Bejerano G, Wagner EG, Margalit H, Altuvia S (2001). "Novel small RNA-encoding genes in the intergenic regions of Escherichia coli". Curr Biol 11: 941–950. doi:10.1016/S0960-9822(01)00270-6. PMID 11448770.
- ^ Udekwu KI, Darfeuille F, Vogel J, Reimegård J, Holmqvist E, Wagner EG (2005). "Hfq-dependent regulation of OmpA synthesis is mediated by an antisense RNA". Genes Dev. 19 (19): 2355–66. doi:10.1101/gad.354405. PMID 16204185.
- ^ Udekwu KI, Wagner EG (2007). "Sigma E controls biogenesis of the antisense RNA MicA". Nucleic Acids Res. 35 (4): 1279–88. doi:10.1093/nar/gkl1154. PMID 17267407.
- ^ Johansen J, Rasmussen AA, Overgaard M, Valentin-Hansen P (2006). "Conserved small non-coding RNAs that belong to the sigmaE regulon: role in down-regulation of outer membrane proteins". J. Mol. Biol. 364 (1): 1–8. doi:10.1016/j.jmb.2006.09.004. PMID 17007876.
[edit] External links
