Squamous cell carcinoma

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Squamous cell carcinoma, NOS
Classification and external resources
SCC of the skin tends to arise from pre-malignant lesions, actinic keratoses; surface is usually scaly and often ulcerates (as shown here).
ICD-10 C44
ICD-9 173
ICD-O: M8070/3
MedlinePlus 000829
eMedicine derm/401 

In medicine, squamous cell carcinoma (SCC) is a form of cancer of the carcinoma type that may occur in many different organs, including the skin, lips, mouth, esophagus, urinary bladder, prostate, lungs, vagina, and cervix. It is a malignant tumor of squamous epithelium (epithelium that shows squamous cell differentiation).

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[edit] Terminology

A large squamous cell carcinoma of the tongue.
A large squamous cell carcinoma of the tongue.

A carcinoma can be characterized as either in situ (confined to the original site) or invasive, depending on whether the cancer invades underlying tissues; only invasive cancers are able to spread to other organs and cause metastasis.

[edit] Sites

[edit] Skin

Squamous cell carcinoma is the second most common cancer of the skin (after basal cell carcinoma but more common than melanoma). It usually occurs in areas exposed to the sun, and can generally be treated by excision only. Sunlight exposure and immunosuppression are risk factors for SCC of the skin. The risk of metastasis is larger than with basal cell carcinoma.

[edit] Head and neck cancer

Biopsy of a highly differentiated squamous cell carcinoma of the mouth. Haematoxylin & eosin stain.
Biopsy of a highly differentiated squamous cell carcinoma of the mouth. Haematoxylin & eosin stain.

Most cases of head and neck cancer (cancer of the mouth, nasal cavity, throat and associated structures) are due to squamous cell carcinoma. Symptoms may include a poorly healing mouth ulcer, a hoarse voice or other persistent problems in the area. Treatment is usually with surgery (which may be extensive) and radiotherapy. Risk factors include smoking and alcohol consumption.

[edit] Esophagus

Esophageal cancer may be due to either squamous cell carcinoma (ESCC) or adenocarcinoma (EAC). SCCs tend to occur closer to the mouth, while adenocarcinomas occur closer to the stomach. Dysphagia (difficulty swallowing, solids worse than liquids) and odynophagia are common initial symptoms. If the disease is localized, esophagectomy may offer the possibility of a cure. If the disease has spread, chemotherapy and radiotherapy are commonly used.

[edit] Lung

Photograph of a squamous cell carcinoma. Tumour is on the left, obstructing the bronchus (lung). Beyond the tumour the bronchus is inflammed and contains mucus.
Photograph of a squamous cell carcinoma. Tumour is on the left, obstructing the bronchus (lung). Beyond the tumour the bronchus is inflammed and contains mucus.

When associated with the lung, it often causes ectopic production of parathyroid hormone-related protein (PTHrP), resulting in hypercalcemia.

[edit] Prostate

When associated with the prostate, squamous cell carcinoma is very aggressive in nature. It is difficult to detect as there is no increase in prostate specific antigen levels seen; meaning that the cancer is often diagnosed at an advanced stage.

[edit] Vagina and cervix

Vaginal squamous cell carcinoma spreads slowly and usually stays near the vagina, but may spread to the lungs and liver. This is the most common type of vaginal cancer.

[edit] Experimental treatments

In 2007, Australian biopharmaceutical company Clinuvel Pharmaceuticals Limited began clinical trials with a melanocyte-stimulating hormone called melanotan which they refer to with the proprietary name CUV1647 to provide photoprotection for organ transplant patients against squamous cell carcinoma of the skin and actinic keratosis.[1][2]

[edit] Related conditions

  • Keratoacanthoma is a low-grade malignancy of the skin. It originates in the pilo-sebaceous glands, and is similar in clinical presentation and microscopic analysis to squamous cell carcinoma, except that it contains a central keratin plug. Statistically, it is less likely to become invasive than squamous cell carcinoma.
  • Bowen's disease is a sunlight-induced skin disease, and is considered to be an early form of squamous cell carcinoma.
  • Marjolin's ulcer is a type of squamous cell carcinoma that arises from a non-healing ulcer or burn wound.

[edit] External links

v • d • e
Epithelial neoplasms (ICD-O 8010-8799)
Papilloma/carcinoma (8010-8139)
Adenomas/adenocarcinomas (8140-8429)
Adnexal And Skin appendage (8390-8429)
sweat gland (Hidrocystoma, Syringoma)
Cystic, Mucinous And Serous (8440-8499)
Ductal, Lobular And Medullary (8500-8549)
Acinar cell (8550-8559)
Complex epithelial (8560-8589)
Gonadal (8590-8679)
Paragangliomas And Glomus tumors (8680-8719)
Nevi and melanomas (8720-8799)