SPTAN1

From Wikipedia, the free encyclopedia

Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin)

PDB rendering based on 1aey.

Available structures: 1aey, 1aj3, 1bk2, 1cun, 1e6g, 1e6h, 1e7o, 1h8k, 1hd3, 1m8m, 1pwt, 1qkw, 1qkx, 1shg, 1u06, 1u4q, 1u5p, 1uue, 2cdt, 2f2v, 2f2w, 2f2x, 2fot, 2jm8, 2jm9, 2jma, 2nuz

Identifiers

Symbol(s)

SPTAN1; (ALPHA)II-SPECTRIN; FLJ44613

External IDs

OMIM: 182810 MGI: 98386 HomoloGene: 2353

Gene ontology
Molecular Function:	• actin binding • structural constituent of cytoskeleton • calcium ion binding • calmodulin binding
Cellular Component:	• membrane fraction • cytoskeleton • spectrin • membrane
Biological Process:	• barbed-end actin filament capping

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_003127 (mRNA)
NP_003118 (protein)

XM_001000210 (mRNA)
XP_001000210 (protein)

Location

Chr 9: 130.35 - 130.44 Mb

Chr 2: 29.79 - 29.85 Mb

Pubmed search

[1]

[2]

Spectrin, alpha, non-erythrocytic 1 (alpha-fodrin), also known as SPTAN1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SPTAN1 spectrin, alpha, non-erythrocytic 1 (alpha-fodrin).

[edit] Further reading

Chow CW (1999). "Regulation and intracellular localization of the epithelial isoforms of the Na+/H+ exchangers NHE2 and NHE3.". Clinical and investigative medicine. Médecine clinique et experimentale 22 (5): 195–206. PMID 10579058.
Hayashi Y, Arakaki R, Ishimaru N (2003). "The role of caspase cascade on the development of primary Sjögren's syndrome.". J. Med. Invest. 50 (1-2): 32–8. PMID 12630566.
Bennett V (1979). "Immunoreactive forms of human erythrocyte ankyrin are present in diverse cells and tissues.". Nature 281 (5732): 597–9. PMID 492324.
Frappier T, Stetzkowski-Marden F, Pradel LA (1991). "Interaction domains of neurofilament light chain and brain spectrin.". Biochem. J. 275 ( Pt 2): 521–7. PMID 1902666.
Bennett AF, Hayes NV, Baines AJ (1991). "Site specificity in the interactions of synapsin 1 with tubulin.". Biochem. J. 276 ( Pt 3): 793–9. PMID 1905928.
Davis LH, Bennett V (1990). "Mapping the binding sites of human erythrocyte ankyrin for the anion exchanger and spectrin.". J. Biol. Chem. 265 (18): 10589–96. PMID 2141335.
Moon RT, McMahon AP (1990). "Generation of diversity in nonerythroid spectrins. Multiple polypeptides are predicted by sequence analysis of cDNAs encompassing the coding region of human nonerythroid alpha-spectrin.". J. Biol. Chem. 265 (8): 4427–33. PMID 2307671.
Langley RC, Cohen CM (1986). "Association of spectrin with desmin intermediate filaments.". J. Cell. Biochem. 30 (2): 101–9. doi:10.1002/jcb.240300202. PMID 2939097.
Cianci CD, Giorgi M, Morrow JS (1988). "Phosphorylation of ankyrin down-regulates its cooperative interaction with spectrin and protein 3.". J. Cell. Biochem. 37 (3): 301–15. doi:10.1002/jcb.240370305. PMID 2970468.
Steiner JP, Bennett V (1988). "Ankyrin-independent membrane protein-binding sites for brain and erythrocyte spectrin.". J. Biol. Chem. 263 (28): 14417–25. PMID 2971657.
Herrmann H, Wiche G (1987). "Plectin and IFAP-300K are homologous proteins binding to microtubule-associated proteins 1 and 2 and to the 240-kilodalton subunit of spectrin.". J. Biol. Chem. 262 (3): 1320–5. PMID 3027087.
McMahon AP, Giebelhaus DH, Champion JE, et al. (1987). "cDNA cloning, sequencing and chromosome mapping of a non-erythroid spectrin, human alpha-fodrin.". Differentiation 34 (1): 68–78. PMID 3038643.
Frappier T, Regnouf F, Pradel LA (1988). "Binding of brain spectrin to the 70-kDa neurofilament subunit protein.". Eur. J. Biochem. 169 (3): 651–7. PMID 3121319.
Leto TL, Fortugno-Erikson D, Barton D, et al. (1988). "Comparison of nonerythroid alpha-spectrin genes reveals strict homology among diverse species.". Mol. Cell. Biol. 8 (1): 1–9. PMID 3336352.
McMahon AP, Moon RT (1988). "Structure and evolution of a non-erythroid spectrin, human alpha-fodrin.". Biochem. Soc. Trans. 15 (5): 804–7. PMID 3691949.
Lundberg S, Björk J, Löfvenberg L, Backman L (1995). "Cloning, expression and characterization of two putative calcium-binding sites in human non-erythroid alpha-spectrin.". Eur. J. Biochem. 230 (2): 658–65. PMID 7607240.
Hughes CA, Bennett V (1995). "Adducin: a physical model with implications for function in assembly of spectrin-actin complexes.". J. Biol. Chem. 270 (32): 18990–6. PMID 7642559.
Gregorio CC, Repasky EA, Fowler VM, Black JD (1994). "Dynamic properties of ankyrin in T lymphocytes: colocalization with spectrin and protein kinase C beta.". J. Cell Biol. 125 (2): 345–58. PMID 8163551.
Li X, Bennett V (1996). "Identification of the spectrin subunit and domains required for formation of spectrin/adducin/actin complexes.". J. Biol. Chem. 271 (26): 15695–702. PMID 8663089.
Stabach PR, Cianci CD, Glantz SB, et al. (1997). "Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility.". Biochemistry 36 (1): 57–65. doi:10.1021/bi962034i. PMID 8993318.