SPRY4

From Wikipedia, the free encyclopedia

Sprouty homolog 4 (Drosophila)

Identifiers

External IDs

OMIM: 607984 MGI: 1345144 HomoloGene: 8042

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• membrane
Biological Process:	• multicellular organismal development • regulation of signal transduction • negative regulation of MAPK activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_030964 (mRNA)
NP_112226 (protein)

XM_988191 (mRNA)
XP_993285 (protein)

Location

Chr 5: 141.67 - 141.68 Mb

Chr 18: 38.71 - 38.73 Mb

Pubmed search

[1]

[2]

Sprouty homolog 4 (Drosophila), also known as SPRY4, is a human gene.^[1]

SPRY4 is an inhibitor of the receptor-transduced mitogen-activated protein kinase (MAPK) signaling pathway. It is positioned upstream of RAS (see HRAS; MIM 190020) activation and impairs the formation of active GTP-RAS (Leeksma et al., 2002).[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SPRY4 sprouty homolog 4 (Drosophila).

[edit] Further reading

Zaharieva I, Georgieva L, Nikolov I, et al.. "Association study in the 5q31-32 linkage region for schizophrenia using pooled DNA genotyping.". BMC psychiatry 8: 11. doi:10.1186/1471-244X-8-11. PMID 18298822.
Cabrita MA, Jäggi F, Widjaja SP, Christofori G (2006). "A functional interaction between sprouty proteins and caveolin-1.". J. Biol. Chem. 281 (39): 29201-2912. doi:10.1074/jbc.M603921200. PMID 16877379.
Katoh Y, Katoh M (2006). "FGF signaling inhibitor, SPRY4, is evolutionarily conserved target of WNT signaling pathway in progenitor cells.". Int. J. Mol. Med. 17 (3): 529-32. PMID 16465403.
Wang J, Thompson B, Ren C, et al. (2006). "Sprouty4, a suppressor of tumor cell motility, is down regulated by DNA methylation in human prostate cancer.". Prostate 66 (6): 613-24. doi:10.1002/pros.20353. PMID 16388505.
Ding W, Bellusci S, Shi W, Warburton D (2004). "Genomic structure and promoter characterization of the human Sprouty4 gene, a novel regulator of lung morphogenesis.". Am. J. Physiol. Lung Cell Mol. Physiol. 287 (1): L52-9. doi:10.1152/ajplung.00430.2003. PMID 14977631.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039.
Sasaki A, Taketomi T, Kato R, et al. (2003). "Mammalian Sprouty4 suppresses Ras-independent ERK activation by binding to Raf1.". Nat. Cell Biol. 5 (5): 427-32. doi:10.1038/ncb978. PMID 12717443.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932.
Leeksma OC, Van Achterberg TA, Tsumura Y, et al. (2002). "Human sprouty 4, a new ras antagonist on 5q31, interacts with the dual specificity kinase TESK1.". Eur. J. Biochem. 269 (10): 2546-56. PMID 12027893.