SPRY1

From Wikipedia, the free encyclopedia

Sprouty homolog 1, antagonist of FGF signaling (Drosophila)

Identifiers

SPRY1; hSPRY1

External IDs

OMIM: 602465 MGI: 1345139 HomoloGene: 4266

Gene ontology
Molecular Function:	• protein binding
Cellular Component:	• cytoplasm • membrane • lamellipodium
Biological Process:	• ureteric bud development • induction of an organ • multicellular organismal development • regulation of signal transduction • negative regulation of MAPK activity

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005841 (mRNA)
NP_005832 (protein)

XM_987831 (mRNA)
XP_992925 (protein)

Location

Chr 4: 124.54 - 124.54 Mb

Chr 3: 37.83 - 37.84 Mb

Pubmed search

[1]

[2]

Sprouty homolog 1, antagonist of FGF signaling (Drosophila), also known as SPRY1, is a human gene.^[1]

[edit] References

^ Entrez Gene: SPRY1 sprouty homolog 1, antagonist of FGF signaling (Drosophila).

[edit] Further reading

Hacohen N, Kramer S, Sutherland D, et al. (1998). "sprouty encodes a novel antagonist of FGF signaling that patterns apical branching of the Drosophila airways.". Cell 92 (2): 253–63. PMID 9458049.
Lim J, Wong ES, Ong SH, et al. (2000). "Sprouty proteins are targeted to membrane ruffles upon growth factor receptor tyrosine kinase activation. Identification of a novel translocation domain.". J. Biol. Chem. 275 (42): 32837–45. doi:10.1074/jbc.M002156200. PMID 10887178.
Egan JE, Hall AB, Yatsula BA, Bar-Sagi D (2002). "The bimodal regulation of epidermal growth factor signaling by human Sprouty proteins.". Proc. Natl. Acad. Sci. U.S.A. 99 (9): 6041–6. doi:10.1073/pnas.052090899. PMID 11983899.
Hanafusa H, Torii S, Yasunaga T, Nishida E (2004). "Sprouty1 and Sprouty2 provide a control mechanism for the Ras/MAPK signalling pathway.". Nat. Cell Biol. 4 (11): 850–8. doi:10.1038/ncb867. PMID 12402043.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Di Y, Li J, Zhang Y, et al. (2004). "HCC-associated protein HCAP1, a variant of GEMIN4, interacts with zinc-finger proteins.". J. Biochem. 133 (6): 713–8. PMID 12869526.
Wang L, Ji C, Wu H, et al. (2004). "Identification and expression analysis of a novel splice variant of human Sprouty1 gene.". Int. J. Mol. Med. 12 (5): 783–7. PMID 14533010.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Anteby EY, Natanson-Yaron S, Greenfield C, et al. (2005). "Human placental Hofbauer cells express sprouty proteins: a possible modulating mechanism of villous branching.". Placenta 26 (6): 476–83. doi:10.1016/j.placenta.2004.08.008. PMID 15950061.
Cabrita MA, Jäggi F, Widjaja SP, Christofori G (2006). "A functional interaction between sprouty proteins and caveolin-1.". J. Biol. Chem. 281 (39): 29201–2912. doi:10.1074/jbc.M603921200. PMID 16877379.
Fritzsche S, Kenzelmann M, Hoffmann MJ, et al. (2007). "Concomitant down-regulation of SPRY1 and SPRY2 in prostate carcinoma.". Endocr. Relat. Cancer 13 (3): 839–49. doi:10.1677/erc.1.01190. PMID 16954433.