SPRR3

From Wikipedia, the free encyclopedia

Small proline-rich protein 3

Identifiers

External IDs

OMIM: 182271 MGI: 1330237 HomoloGene: 22638

Gene ontology
Molecular Function:	• structural molecule activity • protein binding
Cellular Component:	• cornified envelope
Biological Process:	• epidermis development • keratinocyte differentiation • keratinization • wound healing

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_005416 (mRNA)
NP_005407 (protein)

NM_011478 (mRNA)
NP_035608 (protein)

Location

Chr 1: 151.24 - 151.24 Mb

Chr 3: 92.54 - 92.54 Mb

Pubmed search

[1]

[2]

Small proline-rich protein 3, also known as SPRR3, is a human gene.^[1]

[edit] References

^ Entrez Gene: SPRR3 small proline-rich protein 3.

[edit] Further reading

Greco MA, Lorand L, Lane WS, et al. (1995). "The pancornulins: a group of small proline rich-related cornified envelope precursors with bifunctional capabilities in isopeptide bond formation.". J. Invest. Dermatol. 104 (2): 204–10. PMID 7829876.
Robinson PA, Marley JJ, High AS, Hume WJ (1994). "Differential expression of protease inhibitor and small proline-rich protein genes between normal human oral tissue and odontogenic keratocysts.". Arch. Oral Biol. 39 (3): 251–9. PMID 8018055.
Gibbs S, Fijneman R, Wiegant J, et al. (1993). "Molecular characterization and evolution of the SPRR family of keratinocyte differentiation markers encoding small proline-rich proteins.". Genomics 16 (3): 630–7. doi:10.1006/geno.1993.1240. PMID 8325635.
Abraham JM, Wang S, Suzuki H, et al. (1997). "Esophagin cDNA cloning and characterization: a tissue-specific member of the small proline-rich protein family that is not expressed in esophageal tumors.". Cell Growth Differ. 7 (7): 855–60. PMID 8809402.
Steinert PM, Marekov LN (1997). "Direct evidence that involucrin is a major early isopeptide cross-linked component of the keratinocyte cornified cell envelope.". J. Biol. Chem. 272 (3): 2021–30. PMID 8999895.
Steinert PM, Candi E, Kartasova T, Marekov L (1998). "Small proline-rich proteins are cross-bridging proteins in the cornified cell envelopes of stratified squamous epithelia.". J. Struct. Biol. 122 (1-2): 76–85. doi:10.1006/jsbi.1998.3957. PMID 9724607.
Fischer DF, Sark MW, Lehtola MM, et al. (1999). "Structure and evolution of the human SPRR3 gene: implications for function and regulation.". Genomics 55 (1): 88–99. doi:10.1006/geno.1998.5622. PMID 9889002.
Steinert PM, Candi E, Tarcsa E, et al. (2000). "Transglutaminase crosslinking and structural studies of the human small proline rich 3 protein.". Cell Death Differ. 6 (9): 916–30. doi:10.1038/sj.cdd.4400568. PMID 10510474.
Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags.". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. PMID 10737800.
Marenholz I, Zirra M, Fischer DF, et al. (2001). "Identification of human epidermal differentiation complex (EDC)-encoded genes by subtractive hybridization of entire YACs to a gridded keratinocyte cDNA library.". Genome Res. 11 (3): 341–55. doi:10.1101/gr.114801. PMID 11230159.
Cabral A, Voskamp P, Cleton-Jansen AM, et al. (2001). "Structural organization and regulation of the small proline-rich family of cornified envelope precursors suggest a role in adaptive barrier function.". J. Biol. Chem. 276 (22): 19231–7. doi:10.1074/jbc.M100336200. PMID 11279051.
Candi E, Oddi S, Terrinoni A, et al. (2001). "Transglutaminase 5 cross-links loricrin, involucrin, and small proline-rich proteins in vitro.". J. Biol. Chem. 276 (37): 35014–23. doi:10.1074/jbc.M010157200. PMID 11443109.
Smolinski KN, Abraham JM, Souza RF, et al. (2002). "Activation of the esophagin promoter during esophageal epithelial cell differentiation.". Genomics 79 (6): 875–80. doi:10.1006/geno.2002.6775. PMID 12036303.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Katou F, Shirai N, Kamakura S, et al. (2003). "Differential expression of cornified cell envelope precursors in normal skin, intraorally transplanted skin and normal oral mucosa.". Br. J. Dermatol. 148 (5): 898–905. PMID 12786819.
Lehr E, Hohl D, Huber M, Brown D (2004). "Infection with Human Papillomavirus alters expression of the small proline rich proteins 2 and 3.". J. Med. Virol. 72 (3): 478–83. doi:10.1002/jmv.20011. PMID 14748073.
Palmeri D, Zuo FR, Rosen SD, Hemmerich S (2004). "Differential gene expression profile of human tonsil high endothelial cells: implications for lymphocyte trafficking.". J. Leukoc. Biol. 75 (5): 910–27. doi:10.1189/jlb.0903408. PMID 14761935.
Kimos MC, Wang S, Borkowski A, et al. (2004). "Esophagin and proliferating cell nuclear antigen (PCNA) are biomarkers of human esophageal neoplastic progression.". Int. J. Cancer 111 (3): 415–7. doi:10.1002/ijc.20267. PMID 15221970.
Hong SH, Nah HY, Lee JY, et al. (2004). "Estrogen regulates the expression of the small proline-rich 2 gene family in the mouse uterus.". Mol. Cells 17 (3): 477–84. PMID 15232223.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.