SPOP

From Wikipedia, the free encyclopedia


Speckle-type POZ protein
PDB rendering based on 2cr2.
Available structures: 2cr2
Identifiers
Symbol(s) SPOP; TEF2
External IDs OMIM: 602650 MGI: 1343085 HomoloGene: 68354
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 8405 20747
Ensembl ENSG00000121067 ENSMUSG00000057522
Uniprot O43791 A0JLP8
Refseq NM_001007226 (mRNA)
NP_001007227 (protein)		 NM_025287 (mRNA)
NP_079563 (protein)
Location Chr 17: 45.03 - 45.11 Mb Chr 11: 95.23 - 95.31 Mb
Pubmed search [1] [2]

Speckle-type POZ protein, also known as SPOP, is a human gene.[1]

This gene encodes a protein that may modulate the transcriptional repression activities of death-associated protein 6 (DAXX), which interacts with histone deacetylase, core histones, and other histone-associated proteins. In mouse, the encoded protein binds to the putative leucine zipper domain of macroH2A1.2, a variant H2A histone that is enriched on inactivated X chromosomes. The BTB/POZ domain of this protein has been shown in other proteins to mediate transcriptional repression and to interact with components of histone deacetylase co-repressor complexes. Alternative splicing of this gene results in multiple transcript variants encoding the same protein.[1]

[edit] References

  1. ^ a b Entrez Gene: SPOP speckle-type POZ protein.

[edit] Further reading

  • Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides.". Gene 138 (1-2): 171-4. PMID 8125298. 
  • Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791-806. PMID 8889548. 
  • Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library.". Gene 200 (1-2): 149-56. PMID 9373149. 
  • Nagai Y, Kojima T, Muro Y, et al. (1998). "Identification of a novel nuclear speckle-type protein, SPOP.". FEBS Lett. 418 (1-2): 23-6. PMID 9414087. 
  • Wu J, Song Y, Bakker AB, et al. (1999). "An activating immunoreceptor complex formed by NKG2D and DAP10.". Science 285 (5428): 730-2. PMID 10426994. 
  • Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination.". Genome Res. 10 (11): 1788-95. PMID 11076863. 
  • Zapata JM, Pawlowski K, Haas E, et al. (2001). "A diverse family of proteins containing tumor necrosis factor receptor-associated factor domains.". J. Biol. Chem. 276 (26): 24242-52. doi:10.1074/jbc.M100354200. PMID 11279055. 
  • Takahashi I, Kameoka Y, Hashimoto K (2002). "MacroH2A1.2 binds the nuclear protein Spop.". Biochim. Biophys. Acta 1591 (1-3): 63-8. PMID 12183056. 
  • Gilfillan S, Ho EL, Cella M, et al. (2002). "NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation.". Nat. Immunol. 3 (12): 1150-5. doi:10.1038/ni857. PMID 12426564. 
  • Diefenbach A, Tomasello E, Lucas M, et al. (2002). "Selective associations with signaling proteins determine stimulatory versus costimulatory activity of NKG2D.". Nat. Immunol. 3 (12): 1142-9. doi:10.1038/ni858. PMID 12426565. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Billadeau DD, Upshaw JL, Schoon RA, et al. (2003). "NKG2D-DAP10 triggers human NK cell-mediated killing via a Syk-independent regulatory pathway.". Nat. Immunol. 4 (6): 557-64. doi:10.1038/ni929. PMID 12740575. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Liu A, Desai BM, Stoffers DA (2004). "Identification of PCIF1, a POZ domain protein that inhibits PDX-1 (MODY4) transcriptional activity.". Mol. Cell. Biol. 24 (10): 4372-83. PMID 15121856. 
  • La M, Kim K, Park J, et al. (2004). "Daxx-mediated transcriptional repression of MMP1 gene is reversed by SPOP.". Biochem. Biophys. Res. Commun. 320 (3): 760-5. doi:10.1016/j.bbrc.2004.06.022. PMID 15240113. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline.". Genome Res. 14 (10B): 2136-44. doi:10.1101/gr.2576704. PMID 15489336. 
  • Hernández-Muñoz I, Lund AH, van der Stoop P, et al. (2005). "Stable X chromosome inactivation involves the PRC1 Polycomb complex and requires histone MACROH2A1 and the CULLIN3/SPOP ubiquitin E3 ligase.". Proc. Natl. Acad. Sci. U.S.A. 102 (21): 7635-40. doi:10.1073/pnas.0408918102. PMID 15897469. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006.". Nucleic Acids Res. 34 (Database issue): D415-8. doi:10.1093/nar/gkj139. PMID 16381901. 
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