SPOCK2

From Wikipedia, the free encyclopedia

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2

Identifiers

SPOCK2; testican-2

External IDs

OMIM: 607988 MGI: 1891351 HomoloGene: 8854

Gene ontology
Molecular Function:	• calcium ion binding
Cellular Component:	• proteinaceous extracellular matrix
Biological Process:	• synaptogenesis • extracellular matrix organization and biogenesis • regulation of cell differentiation

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_014767 (mRNA)
NP_055582 (protein)

NM_052994 (mRNA)
NP_443720 (protein)

Location

Chr 10: 73.49 - 73.52 Mb

Chr 10: 59.5 - 59.53 Mb

Pubmed search

[1]

[2]

Sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2, also known as SPOCK2, is a human gene.^[1]

Proteoglycans, which consist of a core protein and covalently linked glycosaminoglycans, are components of the extracellular matrix. SPOCK2 encodes a member of a novel Ca(2+)-binding proteoglycan family.[supplied by OMIM]^[1]

[edit] References

^ ^a ^b Entrez Gene: SPOCK2 sparc/osteonectin, cwcv and kazal-like domains proteoglycan (testican) 2.

[edit] Further reading

Nagase T, Seki N, Ishikawa K, et al. (1997). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain.". DNA Res. 3 (5): 321–9, 341–54. PMID 9039502.
Vannahme C, Schübel S, Herud M, et al. (1999). "Molecular cloning of testican-2: defining a novel calcium-binding proteoglycan family expressed in brain.". J. Neurochem. 73 (1): 12–20. PMID 10386950.
Nakayama M, Kikuno R, Ohara O (2003). "Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs.". Genome Res. 12 (11): 1773–84. doi:10.1101/gr.406902. PMID 12421765.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Nakada M, Miyamori H, Yamashita J, Sato H (2003). "Testican 2 abrogates inhibition of membrane-type matrix metalloproteinases by other testican family proteins.". Cancer Res. 63 (12): 3364–9. PMID 12810672.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites.". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.