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| Spi-1 (PU.1) 5' UTR regulatory element |
 |
| Type: |
Cis-reg; |
| 2° structure: |
Published; PubMed |
| Seed alignment: |
PubMed |
| Avg length: |
165.2 nucleotides |
| Avg identity: |
89% |
|
The Spi-1 (PU.1) 5' UTR regulatory element is an RNA element found in the 5' UTR of Spi-1 mRNA which is able to inhibit the translation Spi-1 transcripts by 8-fold. Spi-1 regulates myeloid gene expression during haemopoietic development. Mutations in this regulatory region of the 5' UTR can lead to overexpression of Spi-1 which has been linked to development of leukaemia.[1]
[edit] References
- ^ Hensold, JO; Stratton CA, Barth D (1997). "The conserved 5'-untranslated leader of Spi-1 (PU.1) mRNA is highly structured and potently inhibits translation in vitro but not in vivo". Nucleic Acids Res 25: 2869–2876. doi:10.1093/nar/25.14.2869. PMID 9207037.
[edit] External links
