SPINT2

From Wikipedia, the free encyclopedia

Serine peptidase inhibitor, Kunitz type, 2

Identifiers

SPINT2; HAI-2; HAI2; Kop; PB

External IDs

OMIM: 605124 MGI: 1338031 HomoloGene: 7955

Gene ontology
Molecular Function:	• serine-type endopeptidase inhibitor activity
Cellular Component:	• extracellular region • soluble fraction • membrane • integral to membrane
Biological Process:	• cell motility

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_021102 (mRNA)
NP_066925 (protein)

NM_011464 (mRNA)
NP_035594 (protein)

Location

Chr 19: 43.45 - 43.47 Mb

Chr 7: 28.97 - 28.99 Mb

Pubmed search

[1]

[2]

Serine peptidase inhibitor, Kunitz type, 2, also known as SPINT2, is a human gene.^[1]

[edit] References

^ Entrez Gene: SPINT2 serine peptidase inhibitor, Kunitz type, 2.

[edit] Further reading

Morelle W, Capon C, Balduyck M, et al. (1994). "Chondroitin sulphate covalently cross-links the three polypeptide chains of inter-alpha-trypsin inhibitor.". Eur. J. Biochem. 221 (2): 881–8. PMID 7513643.
Mizon C, Balduyck M, Albani D, et al. (1996). "Development of an enzyme-linked immunosorbent assay for human plasma inter-alpha-trypsin inhibitor (ITI) using specific antibodies against each of the H1 and H2 heavy chains.". J. Immunol. Methods 190 (1): 61–70. PMID 8601712.
Gress TM, Müller-Pillasch F, Geng M, et al. (1996). "A pancreatic cancer-specific expression profile.". Oncogene 13 (8): 1819–30. PMID 8895530.
Shimomura T, Denda K, Kitamura A, et al. (1997). "Hepatocyte growth factor activator inhibitor, a novel Kunitz-type serine protease inhibitor.". J. Biol. Chem. 272 (10): 6370–6. PMID 9045658.
Marlor CW, Delaria KA, Davis G, et al. (1997). "Identification and cloning of human placental bikunin, a novel serine protease inhibitor containing two Kunitz domains.". J. Biol. Chem. 272 (18): 12202–8. PMID 9115294.
Kawaguchi T, Qin L, Shimomura T, et al. (1997). "Purification and cloning of hepatocyte growth factor activator inhibitor type 2, a Kunitz-type serine protease inhibitor.". J. Biol. Chem. 272 (44): 27558–64. PMID 9346890.
Blom AM, Thuveson M, Fries E (1998). "Intracellular coupling of bikunin and the heavy chain of rat pre-alpha-inhibitor in COS-1 cells.". Biochem. J. 328 ( Pt 1): 185–91. PMID 9359851.
Müller-Pillasch F, Wallrapp C, Bartels K, et al. (1998). "Cloning of a new Kunitz-type protease inhibitor with a putative transmembrane domain overexpressed in pancreatic cancer.". Biochim. Biophys. Acta 1395 (1): 88–95. PMID 9434156.
Kataoka H, Shimomura T, Kawaguchi T, et al. (2001). "Hepatocyte growth factor activator inhibitor type 1 is a specific cell surface binding protein of hepatocyte growth factor activator (HGFA) and regulates HGFA activity in the pericellular microenvironment.". J. Biol. Chem. 275 (51): 40453–62. doi:10.1074/jbc.M006412200. PMID 11013244.
Itoh H, Kataoka H, Yamauchi M, et al. (2001). "Identification of hepatocyte growth factor activator inhibitor type 2 (HAI-2)-related small peptide (H2RSP): its nuclear localization and generation of chimeric mRNA transcribed from both HAI-2 and H2RSP genes.". Biochem. Biophys. Res. Commun. 288 (2): 390–9. doi:10.1006/bbrc.2001.5767. PMID 11606055.
Suzuki M, Kobayashi H, Fujie M, et al. (2002). "Kunitz-type protease inhibitor bikunin disrupts phorbol ester-induced oligomerization of CD44 variant isoforms containing epitope v9 and subsequently suppresses expression of urokinase-type plasminogen activator in human chondrosarcoma cells.". J. Biol. Chem. 277 (10): 8022–32. doi:10.1074/jbc.M108545200. PMID 11777908.
Kobayashi H, Suzuki M, Kanayama N, et al. (2002). "Suppression of urokinase receptor expression by bikunin is associated with inhibition of upstream targets of extracellular signal-regulated kinase-dependent cascade.". Eur. J. Biochem. 269 (16): 3945–57. PMID 12180971.
Mizon C, Piva F, Queyrel V, et al. (2003). "Urinary bikunin determination provides insight into proteinase/proteinase inhibitor imbalance in patients with inflammatory diseases.". Clin. Chem. Lab. Med. 40 (6): 579–86. PMID 12211652.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Isogai R, Matsukura A, Aragane Y, et al. (2003). "Quantitative analysis of bikunin-laden mast cells in follicular eruptions and chronic skin lesions of atopic dermatitis.". Arch. Dermatol. Res. 294 (9): 387–92. doi:10.1007/s00403-002-0336-9. PMID 12522575.
Yamauchi M, Itoh H, Naganuma S, et al. (2003). "Expression of hepatocyte growth factor activator inhibitor type 2 (HAI-2) in human testis: identification of a distinct transcription start site for the HAI-2 gene in testis.". Biol. Chem. 383 (12): 1953–7. PMID 12553733.
Suzuki M, Kobayashi H, Tanaka Y, et al. (2003). "Suppression of invasion and peritoneal carcinomatosis of ovarian cancer cell line by overexpression of bikunin.". Int. J. Cancer 104 (3): 289–302. doi:10.1002/ijc.10950. PMID 12569552.
Suzuki M, Kobayashi H, Tanaka Y, et al. (2003). "Bikunin target genes in ovarian cancer cells identified by microarray analysis.". J. Biol. Chem. 278 (17): 14640–6. doi:10.1074/jbc.M300239200. PMID 12571229.
Schuster JM, Longo M, Nelson PS (2003). "Differential expression of bikunin (HAI-2/PB), a proposed mediator of glioma invasion, by demethylation treatment.". J. Neurooncol. 64 (3): 219–25. PMID 14558597.
Fukai K, Yokosuka O, Chiba T, et al. (2004). "Hepatocyte growth factor activator inhibitor 2/placental bikunin (HAI-2/PB) gene is frequently hypermethylated in human hepatocellular carcinoma.". Cancer Res. 63 (24): 8674–9. PMID 14695180.