SPINLW1

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Serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin)
Identifiers
Symbol(s) SPINLW1; EPPIN; EPPIN1; EPPIN2; EPPIN3; WAP7; WFDC7; dJ461P17.2
External IDs OMIM: 609031 MGI: 1922776 HomoloGene: 41775
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 57119 75526
Ensembl ENSG00000101448 ENSMUSG00000017733
Uniprot O95925 Q9DA01
Refseq NM_020398 (mRNA)
NP_065131 (protein)		 NM_029325 (mRNA)
NP_083601 (protein)
Location Chr 20: 43.6 - 43.61 Mb Chr 2: 164.28 - 164.28 Mb
Pubmed search [1] [2]

Serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin), also known as SPINLW1, is a human gene.[1]

This gene encodes an epididymal protease inhibitor, which contains both kunitz-type and WAP-type four-disulfide core (WFDC) protease inhibitor consensus sequences. Most WFDC genes are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene is a member of the WFDC gene family and belongs to the telomeric cluster. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[1]

[edit] References

  1. ^ a b Entrez Gene: SPINLW1 serine peptidase inhibitor-like, with Kunitz and WAP domains 1 (eppin).

[edit] Further reading

  • Wang Z, Widgren EE, Sivashanmugam P, et al. (2005). "Association of eppin with semenogelin on human spermatozoa.". Biol. Reprod. 72 (5): 1064-70. doi:10.1095/biolreprod.104.036483. PMID 15590901. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Yenugu S, Richardson RT, Sivashanmugam P, et al. (2005). "Antimicrobial activity of human EPPIN, an androgen-regulated, sperm-bound protein with a whey acidic protein motif.". Biol. Reprod. 71 (5): 1484-90. doi:10.1095/biolreprod.104.031567. PMID 15229136. 
  • Sivashanmugam P, Hall SH, Hamil KG, et al. (2003). "Characterization of mouse Eppin and a gene cluster of similar protease inhibitors on mouse chromosome 2.". Gene 312: 125-34. PMID 12909348. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Clauss A, Lilja H, Lundwall A (2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor domains with homology to whey acidic protein.". Biochem. J. 368 (Pt 1): 233-42. doi:10.1042/BJ20020869. PMID 12206714. 
  • Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20.". Nature 414 (6866): 865-71. doi:10.1038/414865a. PMID 11780052. 
  • Richardson RT, Sivashanmugam P, Hall SH, et al. (2001). "Cloning and sequencing of human Eppin: a novel family of protease inhibitors expressed in the epididymis and testis.". Gene 270 (1-2): 93-102. PMID 11404006. 
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