Sphingosine cholinephosphotransferase

From Wikipedia, the free encyclopedia

In enzymology, a sphingosine cholinephosphotransferase (EC 2.7.8.10) is an enzyme that catalyzes the chemical reaction

CDP-choline + sphingosine CMP + sphingosyl-phosphocholine

Thus, the two substrates of this enzyme are CDP-choline and sphingosine, whereas its two products are CMP and sphingosyl-phosphocholine.

This enzyme belongs to the family of transferases, specifically those transferring non-standard substituted phosphate groups. The systematic name of this enzyme class is CDP-choline:sphingosine cholinephosphotransferase. Other names in common use include CDP-choline-sphingosine cholinephosphotransferase, phosphorylcholine-sphingosine transferase, cytidine diphosphocholine-sphingosine cholinephosphotransferase, and sphingosine choline phosphotransferase. This enzyme participates in sphingolipid metabolism.

[edit] References

• IUBMB entry for 2.7.8.10
• BRENDA references for 2.7.8.10 (Recommended.)
• PubMed references for 2.7.8.10
• PubMed Central references for 2.7.8.10
• Google Scholar references for 2.7.8.10
• Fujino Y, Negishi T, Ito S (1968). "Enzymic synthesis of sphingosylphosphorylcholine". Biochem. J. 109: 310–1. PMID 5679375. 

[edit] External links

The CAS registry number for this enzyme class is 9027-12-7.

• IUBMB entry for 2.7.8.10

• KEGG entry for 2.7.8.10

• BRENDA entry for 2.7.8.10

• NiceZyme view of 2.7.8.10

• EC2PDB: PDB structures for 2.7.8.10

• PRIAM entry for 2.7.8.10

• PUMA2 entry for 2.7.8.10

• IntEnz: Integrated Enzyme entry for 2.7.8.10

• MetaCyc entry for 2.7.8.10

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0047354: sphingosine cholinephosphotransferase

• AMIGO entry for GO code 0047354: sphingosine cholinephosphotransferase