Sphinganine kinase

From Wikipedia, the free encyclopedia

In enzymology, a sphinganine kinase (EC 2.7.1.91) is an enzyme that catalyzes the chemical reaction

ATP + sphinganine ADP + sphinganine 1-phosphate

Thus, the two substrates of this enzyme are ATP and sphinganine, whereas its two products are ADP and sphinganine 1-phosphate.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:sphinganine 1-phosphotransferase. Other names in common use include dihydrosphingosine kinase, dihydrosphingosine kinase (phosphorylating), and sphingosine kinase (phosphorylating). This enzyme participates in 3 metabolic pathways: sphingolipid metabolism, calcium signaling pathway, and vegf signaling pathway.

[edit] References

• IUBMB entry for 2.7.1.91
• BRENDA references for 2.7.1.91 (Recommended.)
• PubMed references for 2.7.1.91
• PubMed Central references for 2.7.1.91
• Google Scholar references for 2.7.1.91
• Stoffel W, Bauer E, Stahl J (1974). "The metabolism of sphingosine bases in Tetrahymena pyriformis Sphingosine kinase and sphingosine-1-phosphate lyase". Hoppe. Seylers. Z. Physiol. Chem. 355: 61–74. PMID 4373374. 
• Stoffel W, Heimann G, Hellenbroich B (1973). "Sphingosine kinase in blood platelets". Hoppe. Seylers. Z. Physiol. Chem. 354: 562–6. PMID 4372149. 

[edit] External links

The CAS registry number for this enzyme class is 50864-48-7.

• IUBMB entry for 2.7.1.91

• KEGG entry for 2.7.1.91

• BRENDA entry for 2.7.1.91

• NiceZyme view of 2.7.1.91

• EC2PDB: PDB structures for 2.7.1.91

• PRIAM entry for 2.7.1.91

• PUMA2 entry for 2.7.1.91

• IntEnz: Integrated Enzyme entry for 2.7.1.91

• MetaCyc entry for 2.7.1.91

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0008481: sphinganine kinase

• AMIGO entry for GO code 0008481: sphinganine kinase