SPhos
From Wikipedia, the free encyclopedia
| SPhos | |
|---|---|
 |
|
| IUPAC name | 2-Dicyclohexylphosphino-2',6'-dimethoxybiphenyl |
| Other names | SPhos |
| Identifiers | |
| CAS number | [657408-07-6] |
| PubChem | |
| Properties | |
| Molecular formula | C26H35O2P |
| Molar mass | 410.53 g/mol |
| Appearance | colorless solid |
| Melting point |
164-166 °C |
| Solubility in water | organic solvents |
| Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa) Infobox disclaimer and references |
|
SPhos is an organophosphorus compound derived from the biphenyl. Its palladium complexes exhibit high activity for Suzuki coupling reactions involving aryl chlorides, which are unreactive with palladium complexes of most other phosphine ligands.[1] The ligand has convenient handling characteristics since it is air-stable.[2]
[edit] See also
[edit] References
- ^ Barder, T.E.; Walker, S.D.; Martinelli, J.R.; Buchwald, S. L. (2005). "New Catalysts for Suzuki-Miyaura Coupling Processes: Scope and Studies of the Effect of Ligand Structure". J. Am. Chem. Soc. 127: 4685-4696. doi:.
- ^ Altman, R.A.; Buchwald, S.L. (2007). "Pd-Catalyzed Suzuki-Miyaura Reactions of Aryl Halides Using Bulky Biarylmonophosphine Ligands". Nature Protocols 2: 3115-3121. doi:.
