Spermidine dehydrogenase

From Wikipedia, the free encyclopedia

In enzymology, a spermidine dehydrogenase (EC 1.5.99.6) is an enzyme that catalyzes the chemical reaction

spermidine + acceptor + H₂O propane-1,3-diamine + 4-aminobutanal + reduced acceptor

The 3 substrates of this enzyme are spermidine, acceptor, and H₂O, whereas its 3 products are propane-1,3-diamine, 4-aminobutanal, and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donor with other acceptors. The systematic name of this enzyme class is spermidine:acceptor oxidoreductase. This enzyme is also called spermidine:(acceptor) oxidoreductase. This enzyme participates in urea cycle and metabolism of amino groups and beta-alanine metabolism. It has 2 cofactors: FAD, and Heme.

[edit] References

• IUBMB entry for 1.5.99.6
• BRENDA references for 1.5.99.6 (Recommended.)
• PubMed references for 1.5.99.6
• PubMed Central references for 1.5.99.6
• Google Scholar references for 1.5.99.6
• Tabor CW, Kellogg PD (1970). "Identification of flavin adenine dinucleotide and heme in a homogeneous spermidine dehydrogenase from Serratia marcescens". J. Biol. Chem. 245: 5424–33. PMID 4918845. 
• Tabor H and Tabor CW (1972). "Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines. IIE2a Speridine dehydrogenase". Adv. Enzymol. Relat. Areas Mol. Biol. 36: 225–226. 

[edit] External links

The CAS registry number for this enzyme class is 9076-64-6.

• IUBMB entry for 1.5.99.6

• KEGG entry for 1.5.99.6

• BRENDA entry for 1.5.99.6

• NiceZyme view of 1.5.99.6

• EC2PDB: PDB structures for 1.5.99.6

• PRIAM entry for 1.5.99.6

• PUMA2 entry for 1.5.99.6

• IntEnz: Integrated Enzyme entry for 1.5.99.6

• MetaCyc entry for 1.5.99.6

• Atomic-resolution structures of enzymes belonging to this class

[edit] Gene Ontology (GO) codes

• EGO entry for GO code 0050289: spermidine dehydrogenase

• AMIGO entry for GO code 0050289: spermidine dehydrogenase