SPEN

From Wikipedia, the free encyclopedia

Spen homolog, transcriptional regulator (Drosophila)

PDB rendering based on 1ow1.

Available structures: 1ow1

Identifiers

Symbol(s)

SPEN; KIAA0929; MINT; RP1-134O19.1; SHARP

External IDs

MGI: 1891706 HomoloGene: 8992

Gene ontology
Molecular Function:	• nucleotide binding • nucleic acid binding • single-stranded DNA binding • transcription factor activity • transcription corepressor activity • RNA binding • protein binding • transcription activator activity
Cellular Component:	• nucleus
Biological Process:	• regulation of transcription from RNA polymerase II promoter • Notch signaling pathway • negative regulation of transcription, DNA-dependent

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_015001 (mRNA)
NP_055816 (protein)

NM_019763 (mRNA)
NP_062737 (protein)

Location

Chr 1: 16.05 - 16.14 Mb

Chr 4: 140.74 - 140.81 Mb

Pubmed search

[1]

[2]

Spen homolog, transcriptional regulator (Drosophila), also known as SPEN, is a human gene.^[1]

This gene encodes a hormone inducible transcriptional repressor. Repression of transcription by this gene product can occur through interactions with other repressors, by the recruitment of proteins involved in histone deacetylation, or through sequestration of transcriptional activators. The product of this gene contains a carboxy-terminal domain that permits binding to other corepressor proteins. This domain also permits interaction with members of the NuRD complex, a nucleosome remodeling protein complex that contains deacetylase activity. In addition, this repressor contains several RNA recognition motifs that confer binding to a steroid receptor RNA coactivator; this binding can modulate the activity of both liganded and nonliganded steroid receptors.^[1]

[edit] References

^ ^a ^b Entrez Gene: SPEN spen homolog, transcriptional regulator (Drosophila).

[edit] Further reading

Ternovskaia LN, Prokhorova LG, Moroz VM (1977). "[Antagonistic interrelationships between the staphylococci and Sarcina isolated from the upper respiratory tracts of virtually healthy persons]". Antibiotiki 21 (12): 1072–5. PMID 1020939.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 6 (1): 63–70. PMID 10231032.
Newberry EP, Latifi T, Towler DA (1999). "The RRM domain of MINT, a novel Msx2 binding protein, recognizes and regulates the rat osteocalcin promoter.". Biochemistry 38 (33): 10678–90. doi:10.1021/bi990967j. PMID 10451362.
Shi Y, Downes M, Xie W, et al. (2001). "Sharp, an inducible cofactor that integrates nuclear receptor repression and activation.". Genes Dev. 15 (9): 1140–51. doi:10.1101/gad.871201. PMID 11331609.
Shi Y, Hon M, Evans RM (2002). "The peroxisome proliferator-activated receptor delta, an integrator of transcriptional repression and nuclear receptor signaling.". Proc. Natl. Acad. Sci. U.S.A. 99 (5): 2613–8. doi:10.1073/pnas.052707099. PMID 11867749.
Oswald F, Kostezka U, Astrahantseff K, et al. (2002). "SHARP is a novel component of the Notch/RBP-Jkappa signalling pathway.". EMBO J. 21 (20): 5417–26. PMID 12374742.
Ariyoshi M, Schwabe JW (2003). "A conserved structural motif reveals the essential transcriptional repression function of Spen proteins and their role in developmental signaling.". Genes Dev. 17 (15): 1909–20. doi:10.1101/gad.266203. PMID 12897056.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Dotzlaw H, Papaioannou M, Moehren U, et al. (2004). "Agonist-antagonist induced coactivator and corepressor interplay on the human androgen receptor.". Mol. Cell. Endocrinol. 213 (1): 79–85. doi:10.1016/j.mce.2003.10.036. PMID 15062576.
Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMID 15302935.
Vadlamudi RK, Manavathi B, Singh RR, et al. (2005). "An essential role of Pak1 phosphorylation of SHARP in Notch signaling.". Oncogene 24 (28): 4591–6. doi:10.1038/sj.onc.1208672. PMID 15824732.
Li J, Wang J, Yang X, et al. (2007). "The Spen homolog Msx2-interacting nuclear target protein interacts with the E2 ubiquitin-conjugating enzyme UbcH8.". Mol. Cell. Biochem. 288 (1-2): 151–7. doi:10.1007/s11010-006-9131-9. PMID 16583136.
Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1.". Nature 441 (7091): 315–21. doi:10.1038/nature04727. PMID 16710414.
Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration.". Cell 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569.
Beausoleil SA, Villén J, Gerber SA, et al. (2006). "A probability-based approach for high-throughput protein phosphorylation analysis and site localization.". Nat. Biotechnol. 24 (10): 1285–92. doi:10.1038/nbt1240. PMID 16964243.
Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Feng Y, Bommer GT, Zhai Y, et al. (2007). "Drosophila split ends homologue SHARP functions as a positive regulator of Wnt/beta-catenin/T-cell factor signaling in neoplastic transformation.". Cancer Res. 67 (2): 482–91. doi:10.1158/0008-5472.CAN-06-2314. PMID 17234755.