SPAG9

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Sperm associated antigen 9
Identifiers
Symbol(s) SPAG9; HSS; KIAA0516; PIG6; FLJ13450; FLJ14006; FLJ34602; HLC4; JLP; MGC117291; MGC14967; MGC74461; PHET
External IDs OMIM: 605430 MGI: 1918084 HomoloGene: 2954
RNA expression pattern

More reference expression data
Orthologs
Human Mouse
Entrez 9043 70834
Ensembl ENSG00000008294 ENSMUSG00000020859
Uniprot O60271 Q5NC73
Refseq NM_003971 (mRNA)
NP_003962 (protein)		 NM_001025428 (mRNA)
NP_001020599 (protein)
Location Chr 17: 46.4 - 46.55 Mb Chr 11: 93.81 - 93.94 Mb
Pubmed search [1] [2]

Sperm associated antigen 9, also known as SPAG9, is a human gene.[1]

Extracellular signals are transduced into cells through mitogen-activated protein kinases. The structural organization of these kinases into specific signaling domains is facilitated by scaffolding proteins involved in closely tethering different kinases so that successive phosphorylation events can occur. The protein encoded by this gene is a scaffolding protein that brings together mitogen-activated protein kinases and their transcription factor targets for the activation of specific signaling pathways. This gene which is abundantly expressed in testicular haploid germ cells encodes a protein that is recognized by sperm-agglutinating antibodies and implicated in infertility.[1]

[edit] References

  1. ^ a b Entrez Gene: SPAG9 sperm associated antigen 9.

[edit] Further reading

  • Ichijo H (1999). "From receptors to stress-activated MAP kinases.". Oncogene 18 (45): 6087-93. doi:10.1038/sj.onc.1203129. PMID 10557099. 
  • Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones.". DNA Res. 9 (3): 99-106. PMID 12168954. 
  • Shankar S, Mohapatra B, Suri A (1998). "Cloning of a novel human testis mRNA specifically expressed in testicular haploid germ cells, having unique palindromic sequences and encoding a leucine zipper dimerization motif.". Biochem. Biophys. Res. Commun. 243 (2): 561-5. doi:10.1006/bbrc.1997.7943. PMID 9480848. 
  • Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro.". DNA Res. 5 (1): 31-9. PMID 9628581. 
  • Lee CM, Onésime D, Reddy CD, et al. (2002). "JLP: A scaffolding protein that tethers JNK/p38MAPK signaling modules and transcription factors.". Proc. Natl. Acad. Sci. U.S.A. 99 (22): 14189-94. doi:10.1073/pnas.232310199. PMID 12391307. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899-903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Yasuoka H, Ihn H, Medsger TA, et al. (2004). "A novel protein highly expressed in testis is overexpressed in systemic sclerosis fibroblasts and targeted by autoantibodies.". J. Immunol. 171 (12): 6883-90. PMID 14662895. 
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs.". Nat. Genet. 36 (1): 40-5. doi:10.1038/ng1285. PMID 14702039. 
  • Bouwmeester T, Bauch A, Ruffner H, et al. (2004). "A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway.". Nat. Cell Biol. 6 (2): 97-105. doi:10.1038/ncb1086. PMID 14743216. 
  • Brill LM, Salomon AR, Ficarro SB, et al. (2004). "Robust phosphoproteomic profiling of tyrosine phosphorylation sites from human T cells using immobilized metal affinity chromatography and tandem mass spectrometry.". Anal. Chem. 76 (10): 2763-72. doi:10.1021/ac035352d. PMID 15144186. 
  • Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130-5. doi:10.1073/pnas.0404720101. PMID 15302935. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121-7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Jagadish N, Rana R, Selvi R, et al. (2005). "Characterization of a novel human sperm-associated antigen 9 (SPAG9) having structural homology with c-Jun N-terminal kinase-interacting protein.". Biochem. J. 389 (Pt 1): 73-82. doi:10.1042/BJ20041577. PMID 15693750. 
  • Jagadish N, Rana R, Mishra D, et al. (2005). "Sperm associated antigen 9 (SPAG9): a new member of c-Jun NH2 -terminal kinase (JNK) interacting protein exclusively expressed in testis.". The Keio journal of medicine 54 (2): 66-71. PMID 16077255. 
  • Guinn BA, Bland EA, Lodi U, et al. (2005). "Humoral detection of leukaemia-associated antigens in presentation acute myeloid leukaemia.". Biochem. Biophys. Res. Commun. 335 (4): 1293-304. doi:10.1016/j.bbrc.2005.08.024. PMID 16112646. 
  • Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173-8. doi:10.1038/nature04209. PMID 16189514. 
  • Rana R, Jagadish N, Garg M, et al. (2006). "Small interference RNA-mediated knockdown of sperm associated antigen 9 having structural homology with c-Jun N-terminal kinase-interacting protein.". Biochem. Biophys. Res. Commun. 340 (1): 158-64. doi:10.1016/j.bbrc.2005.11.168. PMID 16356479. 
  • Rana R, Jagadish N, Garg M, et al. (2007). "Immunogenicity study of recombinant human sperm-associated antigen 9 in bonnet macaque (Macaca radiata).". Hum. Reprod. 21 (11): 2894-900. doi:10.1093/humrep/del068. PMID 16959808. 
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