SPAG11B

From Wikipedia, the free encyclopedia

Sperm associated antigen 11

Identifiers

SPAG11; EP2; EP2C; EP2D; HE2; HE2C; MGC61846; SPAG11B

External IDs

OMIM: 606560 MGI: 3647173 HomoloGene: 83383

Gene ontology
Molecular Function:	• molecular_function
Cellular Component:	• extracellular region
Biological Process:	• defense response • spermatogenesis

Orthologs

Human

Mouse

n/a

Refseq

NM_016512 (mRNA)
NP_057596 (protein)

NM_001034905 (mRNA)
NP_001030077 (protein)

Location

n/a

Chr 8: 19.14 - 19.14 Mb

Pubmed search

[1]

[2]

Sperm associated antigen 11, also known as SPAG11, is a human gene.^[1]

This gene encodes several androgen-dependent, epididymis-specific secretory proteins. The specific functions of these proteins have not been determined, but they are thought to be involved in sperm maturation. Some of the isoforms contain regions of similarity to beta-defensins, a family of antimicrobial peptides. The gene is located on chromosome 8p23 near the defensin gene cluster. Alternative splicing of this gene results in seven transcript variants encoding different isoforms. Two different N-terminal and five different C-terminal protein sequences are encoded by the splice variants. Two additional variants have been described, but their full length sequences have not been determined.^[1]

[edit] References

^ ^a ^b Entrez Gene: SPAG11 sperm associated antigen 11.

[edit] Further reading

Kirchhoff C, Osterhoff C, Habben I, et al. (1990). "Cloning and analysis of mRNAs expressed specifically in the human epididymis.". Int. J. Androl. 13 (2): 155–67. PMID 1693137.
Osterhoff C, Kirchhoff C, Krull N, Ivell R (1994). "Molecular cloning and characterization of a novel human sperm antigen (HE2) specifically expressed in the proximal epididymis.". Biol. Reprod. 50 (3): 516–25. PMID 8167223.
Krull N, Ivell R, Osterhoff C, Kirchhoff C (1993). "Region-specific variation of gene expression in the human epididymis as revealed by in situ hybridization with tissue-specific cDNAs.". Mol. Reprod. Dev. 34 (1): 16–24. doi:10.1002/mrd.1080340104. PMID 8418812.
Hamil KG, Sivashanmugam P, Richardson RT, et al. (2000). "HE2beta and HE2gamma, new members of an epididymis-specific family of androgen-regulated proteins in the human.". Endocrinology 141 (3): 1245–53. PMID 10698202.
Fröhlich O, Po C, Murphy T, Young LG (2000). "Multiple promoter and splicing mRNA variants of the epididymis-specific gene EP2.". J. Androl. 21 (3): 421–30. PMID 10819450.
Fröhlich O, Po C, Young LG (2001). "Organization of the human gene encoding the epididymis-specific EP2 protein variants and its relationship to defensin genes.". Biol. Reprod. 64 (4): 1072–9. PMID 11259252.
von Horsten HH, Derr P, Kirchhoff C (2003). "Novel antimicrobial peptide of human epididymal duct origin.". Biol. Reprod. 67 (3): 804–13. PMID 12193388.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Légaré C, Verville N, Sullivan R (2004). "Vasectomy influences expression of HE1 but not HE2 and HE5 genes in human epididymis.". J. Androl. 25 (1): 30–43. PMID 14662784.
Avellar MC, Honda L, Hamil KG, et al. (2005). "Differential expression and antibacterial activity of epididymis protein 2 isoforms in the male reproductive tract of human and rhesus monkey (Macaca mulatta).". Biol. Reprod. 71 (5): 1453–60. doi:10.1095/biolreprod.104.031740. PMID 15229135.