SPACA3

From Wikipedia, the free encyclopedia

Sperm acrosome associated 3

Identifiers

SPACA3; 1700025M08Rik; ALLP17; LYC3; LYZL3; MGC119058; SLLP1

External IDs

MGI: 1922872 HomoloGene: 18365

Gene ontology
Molecular Function:	• lysozyme activity • bacterial binding
Cellular Component:	• acrosome • extracellular region • membrane • integral to membrane • secretory granule
Biological Process:	• peptidoglycan catabolic process • response to virus • cell wall catabolic process • sperm-egg recognition • monocyte activation • positive regulation of macrophage activation • positive regulation of phagocytosis • defense response to Gram-positive bacterium

RNA expression pattern

More reference expression data

Orthologs

Human

Mouse

Refseq

NM_173847 (mRNA)
NP_776246 (protein)

XM_354632 (mRNA)
XP_354632 (protein)

Location

Chr 17: 28.34 - 28.35 Mb

Chr 11: 80.67 - 80.68 Mb

Pubmed search

[1]

[2]

Sperm acrosome associated 3, also known as SPACA3, is a human gene.^[1]

[edit] References

^ Entrez Gene: SPACA3 sperm acrosome associated 3.

[edit] Further reading

Niyonsaba F, Ogawa H (2006). "Protective roles of the skin against infection: implication of naturally occurring human antimicrobial agents beta-defensins, cathelicidin LL-37 and lysozyme.". J. Dermatol. Sci. 40 (3): 157–68. doi:10.1016/j.jdermsci.2005.07.009. PMID 16150577.
Cramer EM, Breton-Gorius J (1987). "Ultrastructural localization of lysozyme in human neutrophils by immunogold.". J. Leukoc. Biol. 41 (3): 242–7. PMID 3470418.
Welsh IR, Spitznagel JK (1973). "Distribution of lysosomal enzymes, cationic proteins, and bactericidal substances in subcellular fractions of human polymorphonuclear leukocytes.". Infect. Immun. 4 (2): 97–102. PMID 5154881.
Ibrahim HR, Matsuzaki T, Aoki T (2001). "Genetic evidence that antibacterial activity of lysozyme is independent of its catalytic function.". FEBS Lett. 506 (1): 27–32. PMID 11591365.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932.
Mandal A, Klotz KL, Shetty J, et al. (2003). "SLLP1, a unique, intra-acrosomal, non-bacteriolytic, c lysozyme-like protein of human spermatozoa.". Biol. Reprod. 68 (5): 1525–37. doi:10.1095/biolreprod.102.010108. PMID 12606493.
Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment.". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMID 12975309.
Wang Z, Zhang Y, Mandal A, et al. (2005). "The spermatozoa protein, SLLP1, is a novel cancer-testis antigen in hematologic malignancies.". Clin. Cancer Res. 10 (19): 6544–50. doi:10.1158/1078-0432.CCR-04-0911. PMID 15475442.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334.
Zhang K, Gao R, Zhang H, et al. (2006). "Molecular cloning and characterization of three novel lysozyme-like genes, predominantly expressed in the male reproductive system of humans, belonging to the c-type lysozyme/alpha-lactalbumin family.". Biol. Reprod. 73 (5): 1064–71. doi:10.1095/biolreprod.105.041889. PMID 16014814.