SOX3

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SRY (sex determining region Y)-box 3
PDB rendering based on 1gt0.
Available structures: 1gt0, 1o4x
Identifiers
Symbol(s) SOX3; MRGH; SOXB
External IDs OMIM: 313430 MGI98365 HomoloGene4118
RNA expression pattern

More reference expression data

Orthologs
Human Mouse
Entrez 6658 20675
Ensembl ENSG00000134595 ENSMUSG00000045179
Uniprot P41225 Q4VBD8
Refseq NM_005634 (mRNA)
NP_005625 (protein)
XM_988206 (mRNA)
XP_993300 (protein)
Location Chr X: 139.41 - 139.42 Mb Chr X: 57.15 - 57.15 Mb
Pubmed search [1] [2]

SRY (sex determining region Y)-box 3, also known as SOX3, is a human gene.[1]

This gene encodes a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional regulator after forming a protein complex with other proteins. Mutations in this gene have been associated with X-linked mental retardation with growth hormone deficiency.[1]

Contents

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[edit] References

[edit] Further reading

  • Kamachi Y, Uchikawa M, Kondoh H (2000). "Pairing SOX off: with partners in the regulation of embryonic development.". Trends Genet. 16 (4): 182–7. PMID 10729834. 
  • Bowles J, Schepers G, Koopman P (2001). "Phylogeny of the SOX family of developmental transcription factors based on sequence and structural indicators.". Dev. Biol. 227 (2): 239–55. doi:10.1006/dbio.2000.9883. PMID 11071752. 
  • Schepers GE, Teasdale RD, Koopman P (2002). "Twenty pairs of sox: extent, homology, and nomenclature of the mouse and human sox transcription factor gene families.". Dev. Cell 3 (2): 167–70. PMID 12194848. 
  • Denny P, Swift S, Brand N, et al. (1992). "A conserved family of genes related to the testis determining gene, SRY.". Nucleic Acids Res. 20 (11): 2887. PMID 1614875. 
  • Stevanović M, Lovell-Badge R, Collignon J, Goodfellow PN (1994). "SOX3 is an X-linked gene related to SRY.". Hum. Mol. Genet. 2 (12): 2013–8. PMID 8111369. 
  • Collignon J, Sockanathan S, Hacker A, et al. (1996). "A comparison of the properties of Sox-3 with Sry and two related genes, Sox-1 and Sox-2.". Development 122 (2): 509–20. PMID 8625802. 
  • Laumonnier F, Ronce N, Hamel BC, et al. (2003). "Transcription factor SOX3 is involved in X-linked mental retardation with growth hormone deficiency.". Am. J. Hum. Genet. 71 (6): 1450–5. PMID 12428212. 
  • Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMID 12477932. 
  • Aota S, Nakajima N, Sakamoto R, et al. (2003). "Pax6 autoregulation mediated by direct interaction of Pax6 protein with the head surface ectoderm-specific enhancer of the mouse Pax6 gene.". Dev. Biol. 257 (1): 1–13. PMID 12710953. 
  • Weiss J, Meeks JJ, Hurley L, et al. (2003). "Sox3 is required for gonadal function, but not sex determination, in males and females.". Mol. Cell. Biol. 23 (22): 8084–91. PMID 14585968. 
  • Dattani MT (2004). "Borjeson-Forssman-Lehmann syndrome: a novel pituitary phenotype due to mutation in a novel gene.". J. Pediatr. Endocrinol. Metab. 16 (9): 1207–9. PMID 14714741. 
  • Raverot G, Lejeune H, Kotlar T, et al. (2004). "X-linked sex-determining region Y box 3 (SOX3) gene mutations are uncommon in men with idiopathic oligoazoospermic infertility.". J. Clin. Endocrinol. Metab. 89 (8): 4146–8. doi:10.1210/jc.2004-0191. PMID 15292361. 
  • Solomon NM, Ross SA, Morgan T, et al. (2005). "Array comparative genomic hybridisation analysis of boys with X linked hypopituitarism identifies a 3.9 Mb duplicated critical region at Xq27 containing SOX3.". J. Med. Genet. 41 (9): 669–78. doi:10.1136/jmg.2003.016949. PMID 15342697. 
  • Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMID 15489334. 
  • Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X chromosome.". Nature 434 (7031): 325–37. doi:10.1038/nature03440. PMID 15772651. 
  • Savare J, Bonneaud N, Girard F (2005). "SUMO represses transcriptional activity of the Drosophila SoxNeuro and human Sox3 central nervous system-specific transcription factors.". Mol. Biol. Cell 16 (6): 2660–9. doi:10.1091/mbc.E04-12-1062. PMID 15788563. 
  • Woods KS, Cundall M, Turton J, et al. (2005). "Over- and underdosage of SOX3 is associated with infundibular hypoplasia and hypopituitarism.". Am. J. Hum. Genet. 76 (5): 833–49. doi:10.1086/430134. PMID 15800844. 

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This article incorporates text from the United States National Library of Medicine, which is in the public domain.